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    Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) [ Mus musculus (house mouse) ]

    Gene ID: 107951, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk9provided by MGI
    Official Full Name
    cyclin-dependent kinase 9 (CDC2-related kinase)provided by MGI
    Primary source
    MGI:MGI:1328368
    See related
    Ensembl:ENSMUSG00000009555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PITALRE
    Expression
    Ubiquitous expression in ovary adult (RPKM 28.4), thymus adult (RPKM 26.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdk9 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (32705782..32712784, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32561302..32568304, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene endoglin Neighboring gene microRNA 1954 Neighboring gene folylpolyglutamyl synthetase Neighboring gene microRNA 8093 Neighboring gene microRNA 2861 Neighboring gene microRNA 3960

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H2B ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of histone modification ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin/CDK positive transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin/CDK positive transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin/CDK positive transcription elongation factor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 9
    Names
    cell division protein kinase 9
    NP_570930.1
    XP_011237303.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130860.3NP_570930.1  cyclin-dependent kinase 9

      See identical proteins and their annotated locations for NP_570930.1

      Status: VALIDATED

      Source sequence(s)
      AK143217, AL772271
      Consensus CDS
      CCDS15927.1
      UniProtKB/Swiss-Prot
      Q99J95
      Related
      ENSMUSP00000009699.9, ENSMUST00000009699.15
      Conserved Domains (1) summary
      cd07865
      Location:6315
      STKc_CDK9; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      32705782..32712784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239001.1XP_011237303.1  cyclin-dependent kinase 9 isoform X1

      See identical proteins and their annotated locations for XP_011237303.1

      UniProtKB/Swiss-Prot
      Q99J95
      Conserved Domains (1) summary
      cl21453
      Location:1186
      PKc_like; Protein Kinases, catalytic domain
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