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    Thoc5 THO complex 5 [ Mus musculus (house mouse) ]

    Gene ID: 107829, updated on 5-Aug-2018

    Summary

    Official Symbol
    Thoc5provided by MGI
    Official Full Name
    THO complex 5provided by MGI
    Primary source
    MGI:MGI:1351333
    See related
    Ensembl:ENSMUSG00000034274 Vega:OTTMUSG00000005077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fmip; Sgk2; PK1.3; 1700060C24Rik; A430085L24Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 28.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Thoc5 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (4895283..4928867)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4795346..4828868)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 2 pseudogene Neighboring gene nipsnap homolog 1 Neighboring gene microRNA 6918 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 35321 Neighboring gene neurofilament, heavy polypeptide Neighboring gene predicted gene, 39571

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC49541

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
     
    primitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral mRNA export from host cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    THO complex ISO
    Inferred from Sequence Orthology
    more info
     
    THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    THO complex subunit 5 homolog
    Names
    Fms interacting protein
    fms-interacting protein
    serum/glucocorticoid regulated kinase 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172438.3NP_766026.1  THO complex subunit 5 homolog

      See identical proteins and their annotated locations for NP_766026.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645522
      Consensus CDS
      CCDS24393.1
      UniProtKB/Swiss-Prot
      Q8BKT7
      UniProtKB/TrEMBL
      A0A0R4J0J6
      Related
      ENSMUSP00000045580.1, ENSMUST00000038237.7
      Conserved Domains (1) summary
      pfam09766
      Location:97452
      FimP; Fms-interacting protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      4895283..4928867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514448.2XP_006514511.2  THO complex subunit 5 homolog isoform X1

      Conserved Domains (1) summary
      pfam09766
      Location:97464
      FimP; Fms-interacting protein
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