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    Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 [ Mus musculus (house mouse) ]

    Gene ID: 107746, updated on 2-Aug-2021

    Summary

    Official Symbol
    Rapgef1provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 1provided by MGI
    Primary source
    MGI:MGI:104580
    See related
    Ensembl:ENSMUSG00000039844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3G; Grf; Grf2; 4932418O06Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 38.9), spleen adult (RPKM 34.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rapgef1 in Genome Data Viewer
    Location:
    2 B; 2 20.32 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29509732..29630376)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29619720..29740364)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (29475240..29595883)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 27 Neighboring gene microRNA 133c Neighboring gene predicted gene, 30761 Neighboring gene predicted gene 13420 Neighboring gene predicted gene 13547 Neighboring gene TruB pseudouridine (psi) synthase family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nerve growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 1
    Names
    guanine nucleotide releasing factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039086.1NP_001034175.1  rap guanine nucleotide exchange factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001034175.1

      Status: VALIDATED

      Source sequence(s)
      AK077034, AK147470, AK147696
      Consensus CDS
      CCDS38092.1
      UniProtKB/TrEMBL
      Q3UGX8, Q3UHC1, Q8C5V7
      Related
      ENSMUSP00000088680.6, ENSMUST00000091146.12
      Conserved Domains (2) summary
      smart00147
      Location:9771206
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:829970
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    2. NM_001039087.1NP_001034176.1  rap guanine nucleotide exchange factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001034176.1

      Status: VALIDATED

      Source sequence(s)
      AK077034, AK147468
      Consensus CDS
      CCDS38091.1
      UniProtKB/TrEMBL
      Q3UHC1, Q8C5V7
      Related
      ENSMUSP00000092703.5, ENSMUST00000095087.11
      Conserved Domains (2) summary
      smart00147
      Location:9831212
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:835976
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    3. NM_001362702.1NP_001349631.1  rap guanine nucleotide exchange factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK077034, AK147468, BC129881
      Consensus CDS
      CCDS89458.1
      Related
      ENSMUSP00000121615.4, ENSMUST00000147755.10
      Conserved Domains (4) summary
      smart00147
      Location:9441173
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:796937
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:188298
      Atrophin-1; Atrophin-1 family
      cl27601
      Location:663778
      Pectinesterase; Pectinesterase
    4. NM_054050.2NP_473391.1  rap guanine nucleotide exchange factor 1 isoform 3

      See identical proteins and their annotated locations for NP_473391.1

      Status: VALIDATED

      Source sequence(s)
      AF348669, AK077034, AK147470
      Consensus CDS
      CCDS15854.1
      UniProtKB/TrEMBL
      Q3UHC1, Q8C5V7, Q91ZZ2
      Related
      ENSMUSP00000099936.5, ENSMUST00000102872.11
      Conserved Domains (2) summary
      smart00147
      Location:8451074
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:697838
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29509732..29630376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497583.2XP_006497646.1  rap guanine nucleotide exchange factor 1 isoform X2

      Conserved Domains (4) summary
      smart00147
      Location:10151244
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8671008
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:226336
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:677877
      PHA03307; transcriptional regulator ICP4; Provisional
    2. XM_030246484.1XP_030102344.1  rap guanine nucleotide exchange factor 1 isoform X17

      Conserved Domains (3) summary
      smart00147
      Location:8971126
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:749890
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:226336
      PHA03247; large tegument protein UL36; Provisional
    3. XM_036157277.1XP_036013170.1  rap guanine nucleotide exchange factor 1 isoform X4

      Conserved Domains (4) summary
      smart00147
      Location:10141243
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8661007
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:226336
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:676876
      PHA03307; transcriptional regulator ICP4; Provisional
    4. XM_036157284.1XP_036013177.1  rap guanine nucleotide exchange factor 1 isoform X8

      Conserved Domains (4) summary
      smart00147
      Location:9821211
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:834975
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PLN02217
      Location:701816
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      PHA03247
      Location:226336
      PHA03247; large tegument protein UL36; Provisional
    5. XM_036157298.1XP_036013191.1  rap guanine nucleotide exchange factor 1 isoform X13

      Conserved Domains (3) summary
      smart00147
      Location:9451174
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:797938
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:191751
      PHA03247; large tegument protein UL36; Provisional
    6. XM_030246482.1XP_030102342.1  rap guanine nucleotide exchange factor 1 isoform X11

      Conserved Domains (4) summary
      smart00147
      Location:9761205
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:828969
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:188298
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:638838
      PHA03307; transcriptional regulator ICP4; Provisional
    7. XM_030246487.1XP_030102347.1  rap guanine nucleotide exchange factor 1 isoform X22

      Conserved Domains (3) summary
      smart00147
      Location:8071036
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:659800
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:188298
      PHA03247; large tegument protein UL36; Provisional
    8. XM_030246485.2XP_030102345.1  rap guanine nucleotide exchange factor 1 isoform X19

      Conserved Domains (4) summary
      smart00147
      Location:8861115
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:738879
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:97207
      PHA03247; large tegument protein UL36; Provisional
      pfam05110
      Location:566704
      AF-4; AF-4 proto-oncoprotein
    9. XM_030246488.2XP_030102348.1  rap guanine nucleotide exchange factor 1 isoform X23

      Conserved Domains (3) summary
      smart00147
      Location:768997
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:620761
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:97207
      PHA03247; large tegument protein UL36; Provisional
    10. XM_036157280.1XP_036013173.1  rap guanine nucleotide exchange factor 1 isoform X6

      Conserved Domains (4) summary
      smart00147
      Location:9841213
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:836977
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:195305
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:646846
      PHA03307; transcriptional regulator ICP4; Provisional
    11. XM_006497582.4XP_006497645.1  rap guanine nucleotide exchange factor 1 isoform X1

      Conserved Domains (4) summary
      smart00147
      Location:10161245
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8681009
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:678878
      PHA03307; transcriptional regulator ICP4; Provisional
    12. XM_006497585.5XP_006497648.1  rap guanine nucleotide exchange factor 1 isoform X5

      Conserved Domains (3) summary
      smart00147
      Location:9841213
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:836977
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230790
      PHA03247; large tegument protein UL36; Provisional
    13. XM_006497589.4XP_006497652.1  rap guanine nucleotide exchange factor 1 isoform X16

      Conserved Domains (3) summary
      smart00147
      Location:8981127
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:750891
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
    14. XM_006497584.4XP_006497647.1  rap guanine nucleotide exchange factor 1 isoform X3

      Conserved Domains (4) summary
      smart00147
      Location:10151244
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8671008
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:677877
      PHA03307; transcriptional regulator ICP4; Provisional
    15. XM_030246481.2XP_030102341.1  rap guanine nucleotide exchange factor 1 isoform X7

      Conserved Domains (4) summary
      smart00147
      Location:9831212
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:835976
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PLN02217
      Location:702817
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
    16. XM_006497590.4XP_006497653.1  rap guanine nucleotide exchange factor 1 isoform X18

      Conserved Domains (3) summary
      smart00147
      Location:8971126
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:749890
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
    17. XM_006497587.5XP_006497650.1  rap guanine nucleotide exchange factor 1 isoform X12

      Conserved Domains (4) summary
      smart00147
      Location:9641193
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:816957
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
      pfam05110
      Location:644782
      AF-4; AF-4 proto-oncoprotein
    18. XM_036157299.1XP_036013192.1  rap guanine nucleotide exchange factor 1 isoform X15

      Conserved Domains (3) summary
      smart00147
      Location:9321161
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:784925
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:228738
      PHA03247; large tegument protein UL36; Provisional
    19. XM_006497592.4XP_006497655.1  rap guanine nucleotide exchange factor 1 isoform X20

      Related
      ENSMUSP00000158995.2, ENSMUST00000238899.2
      Conserved Domains (3) summary
      smart00147
      Location:8461075
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:698839
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:227337
      PHA03247; large tegument protein UL36; Provisional
    20. XM_006497586.5XP_006497649.1  rap guanine nucleotide exchange factor 1 isoform X9

      Conserved Domains (4) summary
      smart00147
      Location:9781207
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:830971
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:189299
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:640840
      PHA03307; transcriptional regulator ICP4; Provisional
    21. XM_036157288.1XP_036013181.1  rap guanine nucleotide exchange factor 1 isoform X10

      Conserved Domains (4) summary
      smart00147
      Location:9771206
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:829970
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:189299
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:639839
      PHA03307; transcriptional regulator ICP4; Provisional
    22. XM_030246483.2XP_030102343.1  rap guanine nucleotide exchange factor 1 isoform X14

      Conserved Domains (4) summary
      smart00147
      Location:9451174
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:797938
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PLN02217
      Location:664779
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      PHA03247
      Location:189299
      PHA03247; large tegument protein UL36; Provisional
    23. XM_036157304.1XP_036013197.1  rap guanine nucleotide exchange factor 1 isoform X21

      Conserved Domains (3) summary
      smart00147
      Location:8081037
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:660801
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:189299
      PHA03247; large tegument protein UL36; Provisional
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