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    Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 107652, updated on 2-Oct-2018

    Summary

    Official Symbol
    Uap1provided by MGI
    Official Full Name
    UDP-N-acetylglucosamine pyrophosphorylase 1provided by MGI
    Primary source
    MGI:MGI:1334459
    See related
    Ensembl:ENSMUSG00000026670 Vega:OTTMUSG00000023030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AgX; AGX1; AGX-1; AGX-2; SPAG2; ESTM38; AA420407; AA437972
    Expression
    Ubiquitous expression in large intestine adult (RPKM 10.9), colon adult (RPKM 10.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Uap1 in Genome Data Viewer
    Location:
    1; 1 H3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (170141223..170174964, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (172072134..172105077, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene discoidin domain receptor family, member 2 Neighboring gene U2AF homology motif (UHM) kinase 1 Neighboring gene SH2 domain containing 1B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    UDP-N-acetylglucosamine diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    UDP-N-acetylglucosamine diphosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    UDP-N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    UDP-N-acetylhexosamine pyrophosphorylase
    Names
    antigen X
    sperm associated antigen 2
    NP_001291974.1
    NP_001291975.1
    NP_598567.2
    XP_006496669.3
    XP_006496670.1
    XP_006496671.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305045.1NP_001291974.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 1

      See identical proteins and their annotated locations for NP_001291974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA646755, AC119893, AC123650, AI467637, AK036243, AK047566, AK049519, AK081690, BM947026
      Consensus CDS
      CCDS83632.1
      UniProtKB/Swiss-Prot
      Q91YN5
      UniProtKB/TrEMBL
      Q3UHZ7
      Related
      ENSMUSP00000106983.3, OTTMUSP00000026567, ENSMUST00000111351.9, OTTMUST00000055485
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    2. NM_001305046.1NP_001291975.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 3

      See identical proteins and their annotated locations for NP_001291975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.
      Source sequence(s)
      AA646755, AC119893, AC123650, AI467637, AK047566, AK049519, AK081690, BM947026
      Consensus CDS
      CCDS83631.1
      UniProtKB/Swiss-Prot
      Q91YN5
      UniProtKB/TrEMBL
      A0A0R4J1F6
      Related
      ENSMUSP00000106982.3, OTTMUSP00000026568, ENSMUST00000111350.9, OTTMUST00000055486
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    3. NM_133806.5NP_598567.2  UDP-N-acetylhexosamine pyrophosphorylase isoform 2

      See identical proteins and their annotated locations for NP_598567.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AA646755, AC119893, AC123650, AI467637, AK047566, AK049519, AK081690, BM947026
      Consensus CDS
      CCDS15467.1
      UniProtKB/Swiss-Prot
      Q91YN5
      UniProtKB/TrEMBL
      A0A0R4J085
      Related
      ENSMUSP00000027981.7, ENSMUST00000027981.7
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      170141223..170174964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496607.3XP_006496670.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

      Conserved Domains (1) summary
      cd04193
      Location:112434
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    2. XM_006496606.3XP_006496669.3  UDP-N-acetylhexosamine pyrophosphorylase isoform X1

    3. XM_006496608.3XP_006496671.2  UDP-N-acetylhexosamine pyrophosphorylase isoform X3

      See identical proteins and their annotated locations for XP_006496671.2

      UniProtKB/Swiss-Prot
      Q91YN5
      UniProtKB/TrEMBL
      A0A0R4J1F6
      Conserved Domains (1) summary
      cd04193
      Location:88410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
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