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    Pi4kb phosphatidylinositol 4-kinase beta [ Mus musculus (house mouse) ]

    Gene ID: 107650, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pi4kbprovided by MGI
    Official Full Name
    phosphatidylinositol 4-kinase betaprovided by MGI
    Primary source
    MGI:MGI:1334433
    See related
    Ensembl:ENSMUSG00000038861 Vega:OTTMUSG00000019669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM41; Pik4cb; PI4Kbeta; PI4K-beta
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 17.1), bladder adult (RPKM 16.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pi4kb in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (94974731..95006937)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (94778653..94810765)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene RIKEN cDNA B230398E01 gene Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene zinc finger protein 687 Neighboring gene microRNA 7013 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    1-phosphatidylinositol 4-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    phosphatidylinositol phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-kinase beta
    Names
    phosphatidylinositol 4-kinase, catalytic, beta polypeptide
    ptdIns 4-kinase beta
    NP_001280644.1
    NP_001280645.1
    NP_780565.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293715.1NP_001280644.1  phosphatidylinositol 4-kinase beta isoform 1

      See identical proteins and their annotated locations for NP_001280644.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript (1) and encodes the longest isoform (1).
      Source sequence(s)
      AC087062
      Consensus CDS
      CCDS79978.1
      UniProtKB/Swiss-Prot
      Q8BKC8
      Related
      ENSMUSP00000102872.2, OTTMUSP00000021259, ENSMUST00000107251.8, OTTMUST00000047059
      Conserved Domains (1) summary
      cd05168
      Location:529816
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    2. NM_001293716.1NP_001280645.1  phosphatidylinositol 4-kinase beta isoform 3

      See identical proteins and their annotated locations for NP_001280645.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC087062, AK157918, BC113781, BQ443265
      Consensus CDS
      CCDS79979.1
      UniProtKB/Swiss-Prot
      Q8BKC8
      Related
      ENSMUSP00000132150.1, OTTMUSP00000051222, ENSMUST00000167008.7, OTTMUST00000092602
      Conserved Domains (1) summary
      cd05168
      Location:197484
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    3. NM_175356.3NP_780565.2  phosphatidylinositol 4-kinase beta isoform 2

      See identical proteins and their annotated locations for NP_780565.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC087062, AK157918, BQ443265
      Consensus CDS
      CCDS17599.1
      UniProtKB/Swiss-Prot
      Q8BKC8
      Related
      ENSMUSP00000072134.5, OTTMUSP00000021258, ENSMUST00000072287.11, OTTMUST00000047058
      Conserved Domains (1) summary
      cd05168
      Location:514801
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      94974731..95006937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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