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    Ece2 endothelin converting enzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 107522, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ece2provided by MGI
    Official Full Name
    endothelin converting enzyme 2provided by MGI
    Primary source
    MGI:MGI:1101356
    See related
    Ensembl:ENSMUSG00000022842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ece-2; BB127715; 1810009K13Rik; 6330509A19Rik; 9630025D12Rik; Eef1akmt4-Ece2
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.8), CNS E18 (RPKM 4.3) and 28 other tissues See more
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    Genomic context

    See Ece2 in Genome Data Viewer
    Location:
    16; 16 A3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20448601..20464665)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20629851..20645915)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20611674..20645988)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene predicted gene, 49333 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC144385, MGC144386

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptide hormone processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    EEF1AKMT4-ECE2 readthrough transcript protein
    NP_647454.2
    NP_808811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139293.2NP_647454.2  EEF1AKMT4-ECE2 readthrough transcript protein isoform d

      See identical proteins and their annotated locations for NP_647454.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087898, AF489572, AU080537
      Consensus CDS
      CCDS28052.1
      UniProtKB/TrEMBL
      B2RQR8, Q80Z57
      Related
      ENSMUSP00000003898.6, ENSMUST00000003898.12
      Conserved Domains (1) summary
      cd08662
      Location:112761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    2. NM_177942.1NP_808811.1  EEF1AKMT4-ECE2 readthrough transcript protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as 2-b1) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (e, also known as 2b-1) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087898, AF489571, AF489572, AU080537
      Consensus CDS
      CCDS49796.1
      UniProtKB/TrEMBL
      Q80Z57, Q80Z58
      Related
      ENSMUSP00000119693.2, ENSMUST00000133344.8
      Conserved Domains (2) summary
      cd08662
      Location:83732
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72725
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20448601..20464665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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