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    Ece2 endothelin converting enzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 107522, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ece2provided by MGI
    Official Full Name
    endothelin converting enzyme 2provided by MGI
    Primary source
    MGI:MGI:1101356
    See related
    Ensembl:ENSMUSG00000022842 Ensembl:ENSMUSG00000115219 Ensembl:ENSMUSG00000115293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ece-2; BB127715; 1810009K13Rik; 6330509A19Rik; 9630025D12Rik; Eef1akmt4-Ece2
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.8), CNS E18 (RPKM 4.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ece2 in Genome Data Viewer
    Location:
    16; 16 B1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (20611601..20646480)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20611674..20645988)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35685 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase) Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC144385, MGC144386

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    peptide hormone processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    EEF1AKMT4-ECE2 readthrough transcript protein; endothelin-converting enzyme 2
    NP_647454.2
    NP_808811.1
    XP_006521754.2
    XP_006521755.2
    XP_006521756.2
    XP_006521757.2
    XP_006521758.2
    XP_006521759.2
    XP_006521760.2
    XP_006521761.2
    XP_006521763.1
    XP_011244104.1
    XP_017172337.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139293.2NP_647454.2  EEF1AKMT4-ECE2 readthrough transcript protein isoform d

      See identical proteins and their annotated locations for NP_647454.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087898, AF489572, AU080537
      Consensus CDS
      CCDS28052.1
      UniProtKB/TrEMBL
      B2RQR8, Q80Z57
      Related
      ENSMUSP00000003898.5, ENSMUST00000003898.11
      Conserved Domains (1) summary
      cd08662
      Location:112761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    2. NM_177942.1NP_808811.1  EEF1AKMT4-ECE2 readthrough transcript protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as 2-b1) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (e, also known as 2b-1) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC087898, AF489571, AF489572, AU080537
      Consensus CDS
      CCDS49796.1
      UniProtKB/TrEMBL
      Q80Z57, Q80Z58
      Related
      ENSMUSP00000119693.1, ENSMUST00000133344.7
      Conserved Domains (2) summary
      cd08662
      Location:83732
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72725
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      20611601..20646480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521694.3XP_006521757.2  endothelin-converting enzyme 2 isoform X4

      Conserved Domains (2) summary
      cd08662
      Location:112673
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      cl21453
      Location:670706
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006521695.3XP_006521758.2  endothelin-converting enzyme 2 isoform X5

      Conserved Domains (2) summary
      cd08662
      Location:112673
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      cl21453
      Location:670706
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006521693.3XP_006521756.2  endothelin-converting enzyme 2 isoform X3

      Conserved Domains (2) summary
      cd08662
      Location:83644
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      cl21453
      Location:641677
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006521692.3XP_006521755.2  endothelin-converting enzyme 2 isoform X2

      Conserved Domains (2) summary
      cd08662
      Location:112707
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:101720
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    5. XM_006521696.3XP_006521759.2  endothelin-converting enzyme 2 isoform X6

      Conserved Domains (1) summary
      cd08662
      Location:112705
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    6. XM_006521691.3XP_006521754.2  endothelin-converting enzyme 2 isoform X1

      Conserved Domains (2) summary
      cd08662
      Location:112673
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      cl21453
      Location:670706
      PKc_like; Protein Kinases, catalytic domain
    7. XM_006521698.3XP_006521761.2  endothelin-converting enzyme 2 isoform X8

      Conserved Domains (1) summary
      cd08662
      Location:112549
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    8. XM_006521697.3XP_006521760.2  endothelin-converting enzyme 2 isoform X7

      UniProtKB/TrEMBL
      E9Q1S5
      Related
      ENSMUSP00000114039.1, ENSMUST00000122306.7
      Conserved Domains (1) summary
      cd08662
      Location:112706
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    9. XM_017316848.1XP_017172337.1  endothelin-converting enzyme 2 isoform X9

    10. XM_006521700.3XP_006521763.1  endothelin-converting enzyme 2 isoform X10

      See identical proteins and their annotated locations for XP_006521763.1

      Conserved Domains (2) summary
      cd08662
      Location:1395
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      cl21453
      Location:392428
      PKc_like; Protein Kinases, catalytic domain
    11. XM_011245802.2XP_011244104.1  endothelin-converting enzyme 2 isoform X10

      See identical proteins and their annotated locations for XP_011244104.1

      Conserved Domains (2) summary
      cd08662
      Location:1395
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      cl21453
      Location:392428
      PKc_like; Protein Kinases, catalytic domain
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