Format

Send to:

Choose Destination
    • Showing Current items.

    Eprs glutamyl-prolyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 107508, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eprsprovided by MGI
    Official Full Name
    glutamyl-prolyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:97838
    See related
    Ensembl:ENSMUSG00000026615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Qprs; C79379; 2410081F06Rik; 3010002K18Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 17.5), liver E14 (RPKM 12.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See Eprs in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (185361554..185428355)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (187186974..187252234)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 215 Neighboring gene bisphosphate 3'-nucleotidase 1 Neighboring gene RIKEN cDNA 9630028B13 gene Neighboring gene predicted gene 2061 Neighboring gene solute carrier family 30, member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proline-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proline-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    glutamyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-chain fatty acid import ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    prolyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prolyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prolyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    GAIT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT GAIT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional glutamate/proline--tRNA ligase
    Names
    bifunctional aminoacyl-tRNA synthetase
    glutamine-proline-tRNA synthetase
    NP_084011.1
    XP_006497180.1
    XP_006497181.1
    XP_011237210.1
    XP_017176142.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357474.1NP_001344403.1  bifunctional glutamate/proline--tRNA ligase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129195, AC131980
      Conserved Domains (3) summary
      PRK08661
      Location:10261519
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00936
      Location:760809
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      cl27212
      Location:6718
      GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    2. NM_029735.2NP_084011.1  bifunctional glutamate/proline--tRNA ligase isoform 1

      See identical proteins and their annotated locations for NP_084011.1

      Status: VALIDATED

      Source sequence(s)
      AI845980, AK141072, BC058337, BC094679, CB520692, CF537682, CK635189
      Consensus CDS
      CCDS35818.1
      UniProtKB/Swiss-Prot
      Q8CGC7
      Related
      ENSMUSP00000045841.7, ENSMUST00000046514.12
      Conserved Domains (8) summary
      cd10309
      Location:74157
      GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
      PLN02907
      Location:6711
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:10191512
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:10231286
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:12921512
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      pfam00458
      Location:753805
      WHEP-TRS; WHEP-TRS domain
      pfam00749
      Location:197502
      tRNA-synt_1c; tRNA synthetases class I (E and Q), catalytic domain
      pfam03950
      Location:504681
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      185361554..185428355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320653.1XP_017176142.1  bifunctional glutamate/proline--tRNA ligase isoform X3

    2. XM_006497117.3XP_006497180.1  bifunctional glutamate/proline--tRNA ligase isoform X1

      Conserved Domains (3) summary
      PRK08661
      Location:10261519
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00936
      Location:760809
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      cl27212
      Location:6718
      GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    3. XM_006497118.3XP_006497181.1  bifunctional glutamate/proline--tRNA ligase isoform X2

      Conserved Domains (6) summary
      PRK08661
      Location:7691262
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:7731036
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:10421262
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      pfam00458
      Location:503555
      WHEP-TRS; WHEP-TRS domain
      pfam03950
      Location:254431
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      cl00015
      Location:1241
      nt_trans; nucleotidyl transferase superfamily
    4. XM_011238908.2XP_011237210.1  bifunctional glutamate/proline--tRNA ligase isoform X4

      Conserved Domains (5) summary
      PRK08661
      Location:487980
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:491754
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:760980
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      pfam00458
      Location:221273
      WHEP-TRS; WHEP-TRS domain
      pfam03950
      Location:4149
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    Support Center