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    Brms1 breast cancer metastasis-suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 107392, updated on 15-Apr-2019

    Summary

    Official Symbol
    Brms1provided by MGI
    Official Full Name
    breast cancer metastasis-suppressor 1provided by MGI
    Primary source
    MGI:MGI:2388804
    See related
    Ensembl:ENSMUSG00000080268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV003220; AW554636
    Expression
    Ubiquitous expression in testis adult (RPKM 61.2), stomach adult (RPKM 31.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brms1 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (5041232..5049917)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5041404..5049917)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30581 Neighboring gene nuclear encoded tRNA serine 6 (anticodon GCT) Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene Ras and Rab interactor 1 Neighboring gene CD248 antigen, endosialin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: B4gat1

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    breast cancer metastasis-suppressor 1 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134155.2NP_598916.1  breast cancer metastasis-suppressor 1 homolog

      See identical proteins and their annotated locations for NP_598916.1

      Status: VALIDATED

      Source sequence(s)
      BC016108, BY234808
      Consensus CDS
      CCDS50355.1
      UniProtKB/Swiss-Prot
      Q99N20
      UniProtKB/TrEMBL
      Q547N0
      Related
      ENSMUSP00000112266.2, ENSMUST00000116567.3
      Conserved Domains (1) summary
      pfam08598
      Location:60228
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      5041232..5049917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531623.3XP_006531686.1  breast cancer metastasis-suppressor 1 homolog isoform X1

      Conserved Domains (1) summary
      pfam08598
      Location:152320
      Sds3; Sds3-like
    2. XM_006531624.3XP_006531687.1  breast cancer metastasis-suppressor 1 homolog isoform X2

      Conserved Domains (1) summary
      pfam08598
      Location:152269
      Sds3; Sds3-like
    3. XM_006531625.3XP_006531688.1  breast cancer metastasis-suppressor 1 homolog isoform X3

      Conserved Domains (1) summary
      pfam08598
      Location:60177
      Sds3; Sds3-like
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