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    Gbf1 golgi-specific brefeldin A-resistance factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 107338, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gbf1provided by MGI
    Official Full Name
    golgi-specific brefeldin A-resistance factor 1provided by MGI
    Primary source
    MGI:MGI:1861607
    See related
    Ensembl:ENSMUSG00000025224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI035702; AW049900; mKIAA0248; 1700083E03Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 37.5), duodenum adult (RPKM 22.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gbf1 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46140948..46274949)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46152509..46286510)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (46227048..46361000)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Neighboring gene paired-like homeodomain transcription factor 3 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene pleckstrin and Sec7 domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90745, MGC100238

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi to endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum-Golgi intermediate compartment organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of monopolar cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178930.3NP_849261.2  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

      See identical proteins and their annotated locations for NP_849261.2

      Status: PROVISIONAL

      Source sequence(s)
      BC076569
      Consensus CDS
      CCDS29873.1
      UniProtKB/TrEMBL
      Q6DFZ1
      Related
      ENSMUSP00000026254.8, ENSMUST00000026254.14
      Conserved Domains (2) summary
      pfam01369
      Location:699884
      Sec7; Sec7 domain
      pfam12783
      Location:400545
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46140948..46274949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526582.4XP_006526645.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

      Related
      ENSMUST00000176992.8
      Conserved Domains (4) summary
      PHA03247
      Location:17251855
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:4831002
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:699884
      Sec7; Sec7 domain
      pfam12783
      Location:400545
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    2. XM_006526580.4XP_006526643.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:17301860
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:4841003
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:700885
      Sec7; Sec7 domain
      pfam12783
      Location:401546
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    3. XM_006526581.4XP_006526644.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

      Conserved Domains (4) summary
      PHA03247
      Location:17261856
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:4841003
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:700885
      Sec7; Sec7 domain
      pfam12783
      Location:401546
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    4. XM_006526583.3XP_006526646.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:9791109
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:20412
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:16134
      Sec7; Sec7 domain
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