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    UGT2B11 UDP glucuronosyltransferase family 2 member B11 [ Homo sapiens (human) ]

    Gene ID: 10720, updated on 23-Nov-2023

    Summary

    Official Symbol
    UGT2B11provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase family 2 member B11provided by HGNC
    Primary source
    HGNC:HGNC:12545
    See related
    Ensembl:ENSG00000213759 MIM:603064; AllianceGenome:HGNC:12545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver (RPKM 8.5), gall bladder (RPKM 8.1) and 2 other tissues See more
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    Genomic context

    Location:
    4q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69199951..69224984, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72640420..72668386, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70065669..70080466, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase 2A1-like Neighboring gene MPRA-validated peak5051 silencer Neighboring gene uncharacterized LOC105377267 Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B4 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B28

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129611, MGC129612

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic glucuronidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UDP-glucuronosyltransferase 2B11
    Names
    UDP glucuronosyltransferase 2 family, polypeptide B11
    UDP glycosyltransferase 2 family protein
    UDP glycosyltransferase 2 family, polypeptide B11
    UDPGT 2B11
    NP_001064.1
    XP_011529852.1
    XP_016863149.1
    XP_047305499.1
    XP_054204768.1
    XP_054204769.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001073.3NP_001064.1  UDP-glucuronosyltransferase 2B11 precursor

      See identical proteins and their annotated locations for NP_001064.1

      Status: VALIDATED

      Source sequence(s)
      AC111000, AC114797, AF016492, BG184936
      Consensus CDS
      CCDS3527.1
      UniProtKB/Swiss-Prot
      O75310, Q3KNV9
      Related
      ENSP00000387683.1, ENST00000446444.2
      Conserved Domains (1) summary
      pfam00201
      Location:24525
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69199951..69224984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007660.3XP_016863149.1  UDP-glucuronosyltransferase 2B11 isoform X2

    2. XM_047449543.1XP_047305499.1  UDP-glucuronosyltransferase 2B11 isoform X2

    3. XM_011531550.3XP_011529852.1  UDP-glucuronosyltransferase 2B11 isoform X1

      Conserved Domains (2) summary
      PHA03392
      Location:185423
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24441
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      72640420..72668386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348794.1XP_054204769.1  UDP-glucuronosyltransferase 2B11 isoform X2

    2. XM_054348793.1XP_054204768.1  UDP-glucuronosyltransferase 2B11 isoform X1