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    Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 107029, updated on 23-Jun-2021

    Summary

    Official Symbol
    Me2provided by MGI
    Official Full Name
    malic enzyme 2, NAD(+)-dependent, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:2147351
    See related
    Ensembl:ENSMUSG00000024556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NAD-ME; AW120568; D030040L20Rik
    Expression
    Broad expression in large intestine adult (RPKM 31.9), duodenum adult (RPKM 13.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Me2 in Genome Data Viewer
    Location:
    18; 18 E2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73898025..73949326, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73764954..73815438, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (73929694..73975046, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene EGF-like domain 7 pseudogene Neighboring gene elaC ribonuclease Z 1 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene maestro

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables malate dehydrogenase (decarboxylating) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables malic enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NAD-dependent malic enzyme, mitochondrial
    NP_663469.1
    XP_006525559.1
    XP_036016815.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145494.3NP_663469.1  NAD-dependent malic enzyme, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663469.1

      Status: VALIDATED

      Source sequence(s)
      AC132418
      Consensus CDS
      CCDS29339.1
      UniProtKB/Swiss-Prot
      Q99KE1
      Related
      ENSMUSP00000025439.4, ENSMUST00000025439.5
      Conserved Domains (3) summary
      cd05312
      Location:280558
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:28566
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:89270
      malic; Malic enzyme, N-terminal domain

    RNA

    1. NR_157387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132418, AK077746

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      73898025..73949326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160922.1XP_036016815.1  NAD-dependent malic enzyme, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN03129
      Location:1390
      PLN03129; NADP-dependent malic enzyme; Provisional
    2. XM_006525496.4XP_006525559.1  NAD-dependent malic enzyme, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN03129
      Location:35573
      PLN03129; NADP-dependent malic enzyme; Provisional
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