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    CORIN corin, serine peptidase [ Homo sapiens (human) ]

    Gene ID: 10699, updated on 8-Jul-2021

    Summary

    Official Symbol
    CORINprovided by HGNC
    Official Full Name
    corin, serine peptidaseprovided by HGNC
    Primary source
    HGNC:HGNC:19012
    See related
    Ensembl:ENSG00000145244 MIM:605236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRN; ATC2; Lrp4; PEE5; TMPRSS10
    Summary
    This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
    Expression
    Biased expression in heart (RPKM 20.5), skin (RPKM 3.4) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CORIN in Genome Data Viewer
    Location:
    4p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (47594001..47838067, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (47596018..47840084, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5912 Neighboring gene ribosomal protein L21 pseudogene 52 Neighboring gene ATPase phospholipid transporting 10D (putative) Neighboring gene uncharacterized LOC105374444 Neighboring gene uncharacterized LOC105374443 Neighboring gene microRNA 8053 Neighboring gene ribosomal protein L15 pseudogene 7 Neighboring gene VISTA enhancer hs2414 Neighboring gene uncharacterized LOC101927179 Neighboring gene nuclear transcription factor, X-box binding like 1 Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel subunit alpha 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of corin, serine peptidase (CORIN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: NFXL1

    Homology

    Clone Names

    • MGC119742

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    atrial natriuretic peptide-converting enzyme
    Names
    heart-specific serine proteinase ATC2
    pro-ANP-convertase
    pro-ANP-converting enzyme
    transmembrane protease serine 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032679.1 RefSeqGene

      Range
      4976..249042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278585.2NP_001265514.1  atrial natriuretic peptide-converting enzyme isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AF133845, AI378383, AK304038, AK304466
      Consensus CDS
      CCDS75122.1
      UniProtKB/Swiss-Prot
      Q9Y5Q5
      UniProtKB/TrEMBL
      A0A087X1D5, B4E1Y7, B4E2W9
      Related
      ENSP00000484087.1, ENST00000610355.4
      Conserved Domains (6) summary
      cd07445
      Location:69196
      CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd07888
      Location:350471
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      smart00020
      Location:697926
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:586682
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:476510
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:698929
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001278586.2NP_001265515.1  atrial natriuretic peptide-converting enzyme isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame internal exon and multiple 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI338960, AK304466
      Consensus CDS
      CCDS63958.1
      UniProtKB/TrEMBL
      B4E2W9, J3KR83
      Related
      ENSP00000423216.1, ENST00000504584.1
      Conserved Domains (3) summary
      cd07445
      Location:135263
      CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd07888
      Location:417538
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd00112
      Location:543577
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    3. NM_006587.4NP_006578.2  atrial natriuretic peptide-converting enzyme isoform 1

      See identical proteins and their annotated locations for NP_006578.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC092597, AF133845, AI378383, AK304466
      Consensus CDS
      CCDS3477.1
      UniProtKB/Swiss-Prot
      Q9Y5Q5
      UniProtKB/TrEMBL
      B4E2W9
      Related
      ENSP00000273857.4, ENST00000273857.9
      Conserved Domains (7) summary
      cd07445
      Location:135263
      CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      cd07888
      Location:454575
      CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
      smart00020
      Location:8011030
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:690786
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:580614
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:8021033
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:347377
      Ldl_recept_a; Low-density lipoprotein receptor domain class A

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      47594001..47838067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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