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    Slc39a6 solute carrier family 39 (metal ion transporter), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 106957, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc39a6provided by MGI
    Official Full Name
    solute carrier family 39 (metal ion transporter), member 6provided by MGI
    Primary source
    MGI:MGI:2147279
    See related
    Ensembl:ENSMUSG00000024270 AllianceGenome:MGI:2147279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zip6; Ermelin
    Summary
    Predicted to enable monoatomic cation:bicarbonate symporter activity and zinc ion transmembrane transporter activity. Involved in epithelial to mesenchymal transition. Located in endoplasmic reticulum. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human SLC39A6 (solute carrier family 39 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 19.9), CNS E14 (RPKM 19.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Slc39a6 in Genome Data Viewer
    Location:
    18 A2; 18 13.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24712938..24736874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24579881..24603817, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700062C07 gene Neighboring gene predicted gene, 54038 Neighboring gene regulation of nuclear pre-mRNA domain containing 1A Neighboring gene STARR-positive B cell enhancer ABC_E9972 Neighboring gene STARR-seq mESC enhancer starr_44068 Neighboring gene STARR-seq mESC enhancer starr_44069 Neighboring gene STARR-seq mESC enhancer starr_44070 Neighboring gene STARR-seq mESC enhancer starr_44071 Neighboring gene STARR-positive B cell enhancer ABC_E8706 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene molybdenum cofactor sulfurase Neighboring gene STARR-positive B cell enhancer mm9_chr18:24835661-24835962

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic cation:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc transporter ZIP6
    Names
    ZIP-6
    endoplasmic reticulum membrane protein
    endoplasmic reticulum membrane-linked protein
    solute carrier family 39 member 6
    zrt- and Irt-like protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139143.3NP_631882.2  zinc transporter ZIP6 precursor

      See identical proteins and their annotated locations for NP_631882.2

      Status: VALIDATED

      Source sequence(s)
      AK028976, BC055012, CK619600
      Consensus CDS
      CCDS50239.1
      UniProtKB/Swiss-Prot
      Q7TPP9, Q7TQE0, Q8C145, Q8R518
      Related
      ENSMUSP00000064667.4, ENSMUST00000070726.10
      Conserved Domains (1) summary
      pfam02535
      Location:333752
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      24712938..24736874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)