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    CCT6B chaperonin containing TCP1 subunit 6B [ Homo sapiens (human) ]

    Gene ID: 10693, updated on 5-Aug-2018

    Summary

    Official Symbol
    CCT6Bprovided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:1621
    See related
    Ensembl:ENSG00000132141 MIM:610730; Vega:OTTHUMG00000179770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cctz2; CCTZ-2; TSA303; CCT-zeta-2; TCP-1-zeta-2
    Summary
    This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Biased expression in testis (RPKM 57.4) and thyroid (RPKM 1.2) See more
    Orthologs

    Genomic context

    See CCT6B in Genome Data Viewer
    Location:
    17q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (34927859..34981222, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33254878..33307968, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371740 Neighboring gene uncharacterized LOC105371742 Neighboring gene uncharacterized LOC105371741 Neighboring gene zinc finger protein 830 Neighboring gene RAD51L3-RFFL readthrough Neighboring gene DNA ligase 3 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 7 Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase Neighboring gene ribosomal protein L37 pseudogene 22

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    chaperone-mediated protein complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit zeta-2
    Names
    chaperonin containing TCP1, subunit 6B (zeta 2)
    chaperonin-containing T-complex polypeptide 1, subunit 6B
    testis-specific Tcp20
    testis-specific protein TSA303

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193529.2NP_001180458.1  T-complex protein 1 subunit zeta-2 isoform 2

      See identical proteins and their annotated locations for NP_001180458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK301773, DB032371
      Consensus CDS
      CCDS54106.1
      UniProtKB/Swiss-Prot
      Q92526
      Related
      ENSP00000398044.3, OTTHUMP00000262264, ENST00000421975.7, OTTHUMT00000448013
      Conserved Domains (2) summary
      cd03342
      Location:23489
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3493
      chap_CCT_zeta; T-complex protein 1, zeta subunit
    2. NM_001193530.1NP_001180459.1  T-complex protein 1 subunit zeta-2 isoform 3

      See identical proteins and their annotated locations for NP_001180459.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK301773, AK302344, BC027591, DB032371
      Consensus CDS
      CCDS54105.1
      UniProtKB/Swiss-Prot
      Q92526
      Related
      ENSP00000400917.3, OTTHUMP00000262266, ENST00000436961.7, OTTHUMT00000448016
      Conserved Domains (2) summary
      cd03342
      Location:23481
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3485
      chap_CCT_zeta; T-complex protein 1, zeta subunit
    3. NM_006584.3NP_006575.2  T-complex protein 1 subunit zeta-2 isoform 1

      See identical proteins and their annotated locations for NP_006575.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK301773, BC026125, DB032371
      Consensus CDS
      CCDS32617.1
      UniProtKB/Swiss-Prot
      Q92526
      Related
      ENSP00000327191.5, OTTHUMP00000262265, ENST00000314144.9, OTTHUMT00000448014
      Conserved Domains (2) summary
      cd03342
      Location:23526
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3530
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      34927859..34981222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024023.2XP_016879512.1  T-complex protein 1 subunit zeta-2 isoform X1

    2. XM_011524203.3XP_011522505.1  T-complex protein 1 subunit zeta-2 isoform X2

      Conserved Domains (1) summary
      cl02777
      Location:3384
      chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
    3. XM_017024024.2XP_016879513.1  T-complex protein 1 subunit zeta-2 isoform X3

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