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    CENPF centromere protein F [ Homo sapiens (human) ]

    Gene ID: 1063, updated on 5-May-2024

    Summary

    Official Symbol
    CENPFprovided by HGNC
    Official Full Name
    centromere protein Fprovided by HGNC
    Primary source
    HGNC:HGNC:1857
    See related
    Ensembl:ENSG00000117724 MIM:600236; AllianceGenome:HGNC:1857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENF; hcp-1; CILD31; STROMS; PRO1779
    Summary
    This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CENPF in Genome Data Viewer
    Location:
    1q41
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (214603195..214664571)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (213842449..213903796)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214776538..214837914)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 14 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:214656924-214657632 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214678347-214679324 Neighboring gene Sharpr-MPRA regulatory region 6950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:214698971-214699854 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214723608-214724429 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214724430-214725250 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214725251-214726071 Neighboring gene keratin 18 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1815 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:214788162-214789361 Neighboring gene ABHD17A pseudogene 3 Neighboring gene UBE2V1 pseudogene 13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:214856916-214857577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:214900550-214901086 Neighboring gene uncharacterized LOC105372916 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:214996426-214997625 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Stromme syndrome
    MedGen: C1855705 OMIM: 243605 GeneReviews: Stromme Syndrome
    Compare labs

    EBI GWAS Catalog

    Description
    Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates CENPF in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in kinetochore assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in metaphase chromosome alignment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of striated muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to xenobiotic stimulus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ciliary transition fiber IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of outer kinetochore TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in pronucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    centromere protein F
    Names
    AH antigen
    CENP-F kinetochore protein
    cell-cycle-dependent 350K nuclear protein
    centromere protein F, 350/400kDa
    kinetochore protein CENPF
    mitosin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046787.1 RefSeqGene

      Range
      5017..66393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016343.4NP_057427.3  centromere protein F

      See identical proteins and their annotated locations for NP_057427.3

      Status: REVIEWED

      Source sequence(s)
      BG680819, BQ774943, BU155312, BU662228, CD654009, U30872
      Consensus CDS
      CCDS31023.1
      UniProtKB/Swiss-Prot
      P49454, Q13171, Q13246, Q5VVM7
      Related
      ENSP00000355922.3, ENST00000366955.8
      Conserved Domains (6) summary
      COG1196
      Location:9011654
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2831160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:23922887
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam10473
      Location:21312270
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1307
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:29673013
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      214603195..214664571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509082.4XP_011507384.1  centromere protein F isoform X2

      UniProtKB/TrEMBL
      A0A9L9PXU7
      Related
      ENSP00000516538.1, ENST00000706765.1
      Conserved Domains (5) summary
      COG1196
      Location:9011654
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2831160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:21312270
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1307
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:29082954
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
    2. XM_017000086.3XP_016855575.1  centromere protein F isoform X1

      UniProtKB/Swiss-Prot
      P49454, Q13171, Q13246, Q5VVM7
      Conserved Domains (6) summary
      COG1196
      Location:9011654
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2831160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:23922887
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam10473
      Location:21312270
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1307
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:29673013
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      213842449..213903796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333892.1XP_054189867.1  centromere protein F isoform X2

    2. XM_054333891.1XP_054189866.1  centromere protein F isoform X1