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    Prickle1 prickle planar cell polarity protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 106042, updated on 13-Oct-2018

    Summary

    Official Symbol
    Prickle1provided by MGI
    Official Full Name
    prickle planar cell polarity protein 1provided by MGI
    Primary source
    MGI:MGI:1916034
    See related
    Ensembl:ENSMUSG00000036158 Vega:OTTMUSG00000021009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mpk1; Prickle; AW215793; b2b019Clo; 1110058P22Rik
    Expression
    Broad expression in lung adult (RPKM 10.0), cortex adult (RPKM 4.6) and 21 other tissues See more
    Orthologs

    Genomic context

    See Prickle1 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (93499111..93596266, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (93329545..93426322, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type and RNA binding motif 1 Neighboring gene periphilin 1 Neighboring gene predicted gene, 30181 Neighboring gene predicted gene, 41385 Neighboring gene predicted gene, 41387 Neighboring gene zinc finger protein 48, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prickle-like protein 1
    Names
    prickle homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033217.5NP_001028389.1  prickle-like protein 1

      See identical proteins and their annotated locations for NP_001028389.1

      Status: VALIDATED

      Source sequence(s)
      AC124592, AC126556
      Consensus CDS
      CCDS27769.1
      UniProtKB/Swiss-Prot
      Q3U5C7
      Related
      ENSMUSP00000049204.4, OTTMUSP00000023048, ENSMUST00000048982.10
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
    2. NM_001364846.1NP_001351775.1  prickle-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC126556, AK147883, AK153711
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      93499111..93596266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520265.1XP_006520328.1  prickle-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520328.1

      UniProtKB/Swiss-Prot
      Q3U5C7
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
    2. XM_006520266.3XP_006520329.1  prickle-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U5C7
      Related
      ENSMUSP00000104878.2, OTTMUSP00000023049, ENSMUST00000109255.2, OTTMUST00000049664
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
    3. XM_006520264.3XP_006520327.1  prickle-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520327.1

      UniProtKB/Swiss-Prot
      Q3U5C7
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
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