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    Prickle1 prickle planar cell polarity protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 106042, updated on 26-Sep-2022

    Summary

    Official Symbol
    Prickle1provided by MGI
    Official Full Name
    prickle planar cell polarity protein 1provided by MGI
    Primary source
    MGI:MGI:1916034
    See related
    Ensembl:ENSMUSG00000036158 AllianceGenome:MGI:1916034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mpk1; Prickle; b2b019Clo; 1110058P22Rik
    Summary
    Predicted to enable zinc ion binding activity. Acts upstream of or within aorta development and coronary vasculature development. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study autosomal recessive Robinow syndrome and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 10.0), cortex adult (RPKM 4.6) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prickle1 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (93396992..93494147, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (93499111..93596266, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type and RNA binding motif 1 Neighboring gene periphilin 1 Neighboring gene predicted gene, 30181 Neighboring gene predicted gene, 41385 Neighboring gene predicted gene, 41387 Neighboring gene zinc finger protein 48, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anterior visceral endoderm cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular component organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cornea development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton-dependent intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic nail plate morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of bipolar cell polarity involved in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extracellular matrix assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eyelid development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in focal adhesion disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in planar cell polarity pathway involved in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in polarized secretion of basement membrane proteins in epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in primitive streak formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to electrical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tear secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell trailing edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prickle-like protein 1
    Names
    prickle homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033217.5NP_001028389.1  prickle-like protein 1

      See identical proteins and their annotated locations for NP_001028389.1

      Status: VALIDATED

      Source sequence(s)
      AC124592, AC126556
      Consensus CDS
      CCDS27769.1
      UniProtKB/Swiss-Prot
      Q3U5C7
      Related
      ENSMUSP00000049204.5, ENSMUST00000048982.11
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
    2. NM_001364846.1NP_001351775.1  prickle-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC126556, AK147883, AK153711
      Consensus CDS
      CCDS27769.1
      UniProtKB/Swiss-Prot
      Q3U5C7
      Related
      ENSMUSP00000104878.3, ENSMUST00000109255.3
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      93396992..93494147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520265.2XP_006520328.1  prickle-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520328.1

      UniProtKB/Swiss-Prot
      Q3U5C7
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
    2. XM_006520264.5XP_006520327.1  prickle-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006520327.1

      UniProtKB/Swiss-Prot
      Q3U5C7
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle
    3. XM_030248265.2XP_030104125.1  prickle-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U5C7
      Conserved Domains (4) summary
      cd09418
      Location:189244
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:249307
      LIM3_Prickle; The third LIM domain of Prickle
      cd09483
      Location:126184
      LIM1_Prickle_1; The first LIM domain of Prickle 1
      cd09827
      Location:22118
      PET_Prickle; The PET domain of Prickle