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    Gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 106039, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gga1provided by MGI
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by MGI
    Primary source
    MGI:MGI:2146207
    See related
    Ensembl:ENSMUSG00000033128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU016030; AW209092; 4930406E12Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 56.3), duodenum adult (RPKM 51.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gga1 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (78877163..78894585)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (78707620..78725015)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein (Rho GTPase binding) 1 Neighboring gene lectin, galactose-binding, soluble 2 Neighboring gene predicted gene, 26634 Neighboring gene microRNA 6955 Neighboring gene SH3-domain binding protein 1 Neighboring gene pyridoxal (pyridoxine, vitamin B6) phosphatase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 

    Pathways from BioSystems

    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP-ribosylation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to ciliary membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-binding protein GGA1
    Names
    gamma-adaptin-related protein 1
    golgi-localized, gamma ear-containing, ARF-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145929.2NP_666041.1  ADP-ribosylation factor-binding protein GGA1

      See identical proteins and their annotated locations for NP_666041.1

      Status: VALIDATED

      Source sequence(s)
      AL592169
      Consensus CDS
      CCDS27625.1
      UniProtKB/Swiss-Prot
      Q8R0H9
      Related
      ENSMUSP00000035992.7, ENSMUST00000041587.7
      Conserved Domains (5) summary
      smart00809
      Location:513627
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:9147
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      cd14239
      Location:210298
      GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
      pfam06674
      Location:382445
      DUF1176; Protein of unknown function (DUF1176)
      cl00753
      Location:180234
      DUF327; Protein of unknown function (DUF327)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      78877163..78894585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316362.1XP_017171851.1  ADP-ribosylation factor-binding protein GGA1 isoform X1

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