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    SLCO1B1 solute carrier organic anion transporter family member 1B1 [ Homo sapiens (human) ]

    Gene ID: 10599, updated on 19-Jul-2021

    Summary

    Official Symbol
    SLCO1B1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 1B1provided by HGNC
    Primary source
    HGNC:HGNC:10959
    See related
    Ensembl:ENSG00000134538 MIM:604843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6
    Summary
    This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
    Expression
    Restricted expression toward liver (RPKM 119.3) See more
    Orthologs
    NEW
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    Genomic context

    See SLCO1B1 in Genome Data Viewer
    Location:
    12p12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21131194..21239796)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21284128..21392730)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A Neighboring gene solute carrier organic anion transporter family member 1C1 Neighboring gene SLCO1B3-SLCO1B7 readthrough Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene solute carrier organic anion transporter family member 1A2 Neighboring gene islet amyloid polypeptide Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide assessment of variability in human serum metabolism.
    GeneReviews: Not available
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    GeneReviews: Not available
    An atlas of genetic influences on human blood metabolites.
    GeneReviews: Not available
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    GeneReviews: Not available
    Genome-wide association meta-analysis for total serum bilirubin levels.
    GeneReviews: Not available
    Genome-wide study of methotrexate clearance replicates SLCO1B1.
    GeneReviews: Not available
    Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    GeneReviews: Not available
    Human metabolic individuality in biomedical and pharmaceutical research.
    GeneReviews: Not available
    Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.
    GeneReviews: Not available
    Rotor syndrome
    MedGen: C0220991 OMIM: 237450 GeneReviews: Rotor Syndrome
    Compare labs
    Simvastatin response
    MedGen: CN128903 GeneReviews: Not available
    Compare labs
    SLCO1B1 variants and statin-induced myopathy--a genomewide study.
    GeneReviews: Not available
    Statin-induced myopathy
    MedGen: CN181199 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133282

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in bile acid and bile salt transport TAS
    Traceable Author Statement
    more info
     
    involved_in heme catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in organic anion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1B1
    Names
    OATP-2
    liver-specific organic anion transporter 1
    sodium-independent organic anion-transporting polypeptide 2
    solute carrier family 21 (organic anion transporter), member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011745.1 RefSeqGene

      Range
      5001..113603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1022

    mRNA and Protein(s)

    1. NM_006446.5NP_006437.3  solute carrier organic anion transporter family member 1B1

      See identical proteins and their annotated locations for NP_006437.3

      Status: REVIEWED

      Source sequence(s)
      AC022335, AF205071, BC020696
      Consensus CDS
      CCDS8685.1
      UniProtKB/Swiss-Prot
      Q9Y6L6
      UniProtKB/TrEMBL
      A0A024RAU7, Q05CV5
      Related
      ENSP00000256958.2, ENST00000256958.3
      Conserved Domains (3) summary
      cd06174
      Location:31427
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:455508
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:29621
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      21131194..21239796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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