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    POMT1 protein O-mannosyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 10585, updated on 2-Nov-2024

    Summary

    Official Symbol
    POMT1provided by HGNC
    Official Full Name
    protein O-mannosyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:9202
    See related
    Ensembl:ENSG00000130714 MIM:607423; AllianceGenome:HGNC:9202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RT; LGMD2K; MDDGA1; MDDGB1; MDDGC1; LGMDR11
    Summary
    The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
    Expression
    Broad expression in testis (RPKM 20.7), brain (RPKM 7.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See POMT1 in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131502918..131523799)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143715812..143736761)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134378305..134399186)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene proline rich coiled-coil 2B Neighboring gene uncharacterized LOC124902290 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134375403-134376602 Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378091-134378958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378959-134379824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388206-134388706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388707-134389207 Neighboring gene uncharacterized LOC105376301 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134403902-134405101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134405807-134406720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20421 Neighboring gene uridine-cytidine kinase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr9:134426802-134427303 Neighboring gene proline rich transmembrane protein 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein O-linked glycosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein O-linked mannosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein O-mannosyl-transferase 1
    Names
    dolichyl-phosphate-mannose--protein mannosyltransferase 1
    testis tissue sperm-binding protein Li 57p
    NP_001070833.1
    NP_001070834.1
    NP_001129585.1
    NP_001129586.1
    NP_001340122.2
    NP_001340123.1
    NP_001340124.1
    NP_001340125.1
    NP_001340126.2
    NP_001340127.2
    NP_001340128.2
    NP_001340129.1
    NP_001361618.1
    NP_001361619.1
    NP_001361620.1
    NP_001361621.1
    NP_001361622.1
    NP_001361624.1
    NP_001397953.1
    NP_009102.4
    XP_011516442.1
    XP_011516443.1
    XP_011516444.1
    XP_011516445.1
    XP_011516447.1
    XP_047278596.1
    XP_047278597.1
    XP_047278598.1
    XP_054217734.1
    XP_054217735.1
    XP_054217736.1
    XP_054217737.1
    XP_054217738.1
    XP_054217739.1
    XP_054217740.1
    XP_054217741.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008896.2 RefSeqGene

      Range
      5017..25898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_842

    mRNA and Protein(s)

    1. NM_001077365.2NP_001070833.1  protein O-mannosyl-transferase 1 isoform b

      See identical proteins and their annotated locations for NP_001070833.1

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS43894.1
      UniProtKB/TrEMBL
      A0A140VKE0, A0A1V1FTP4
      Related
      ENSP00000385797.4, ENST00000402686.8
      Conserved Domains (4) summary
      smart00472
      Location:299356
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      COG1928
      Location:14720
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
      pfam02366
      Location:20267
      PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
      pfam16192
      Location:520718
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    2. NM_001077366.2NP_001070834.1  protein O-mannosyl-transferase 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS43895.1
      UniProtKB/TrEMBL
      B4DEA0
      Related
      ENSP00000343034.7, ENST00000341012.13
      Conserved Domains (1) summary
      COG1928
      Location:6666
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    3. NM_001136113.2NP_001129585.1  protein O-mannosyl-transferase 1 isoform b

      See identical proteins and their annotated locations for NP_001129585.1

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS43894.1
      UniProtKB/TrEMBL
      A0A140VKE0, A0A1V1FTP4
      Related
      ENSP00000503281.1, ENST00000676640.1
      Conserved Domains (4) summary
      smart00472
      Location:299356
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      COG1928
      Location:14720
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
      pfam02366
      Location:20267
      PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
      pfam16192
      Location:520718
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    4. NM_001136114.2NP_001129586.1  protein O-mannosyl-transferase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS48045.1
      UniProtKB/TrEMBL
      B4DEA0
      Related
      ENSP00000503772.1, ENST00000677216.1
      Conserved Domains (1) summary
      COG1928
      Location:2603
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    5. NM_001353193.2NP_001340122.2  protein O-mannosyl-transferase 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS6943.1
      UniProtKB/Swiss-Prot
      B3KQG0, B4DIF0, Q5JT01, Q5JT06, Q5JT08, Q8NC91, Q8TCA9, Q9NX32, Q9NX82, Q9UNT2, Q9Y6A1
      UniProtKB/TrEMBL
      A0A1V1FTP4
      Conserved Domains (1) summary
      COG1928
      Location:14742
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    6. NM_001353194.2NP_001340123.1  protein O-mannosyl-transferase 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS43895.1
      UniProtKB/TrEMBL
      B4DEA0
      Conserved Domains (1) summary
      COG1928
      Location:6666
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    7. NM_001353195.2NP_001340124.1  protein O-mannosyl-transferase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS48045.1
      UniProtKB/TrEMBL
      B4DEA0
      Conserved Domains (1) summary
      COG1928
      Location:2603
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    8. NM_001353196.2NP_001340125.1  protein O-mannosyl-transferase 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS94516.1
      UniProtKB/TrEMBL
      A0A1V1FTP4, B4DTW4
      Related
      ENSP00000503696.1, ENST00000678303.1
      Conserved Domains (1) summary
      COG1928
      Location:14690
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    9. NM_001353197.2NP_001340126.2  protein O-mannosyl-transferase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL358781
      UniProtKB/TrEMBL
      A0A1V1FTP4
      Conserved Domains (1) summary
      COG1928
      Location:6688
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    10. NM_001353198.2NP_001340127.2  protein O-mannosyl-transferase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL358781
      UniProtKB/TrEMBL
      A0A1V1FTP4
      Conserved Domains (1) summary
      COG1928
      Location:6688
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    11. NM_001353199.2NP_001340128.2  protein O-mannosyl-transferase 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL358781
      UniProtKB/TrEMBL
      B4DEA0
      Conserved Domains (1) summary
      COG1928
      Location:2625
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    12. NM_001353200.2NP_001340129.1  protein O-mannosyl-transferase 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS94518.1
      UniProtKB/TrEMBL
      A0A7I2V2K0, B4DSA5
      Related
      ENSP00000502936.1, ENST00000677029.1
      Conserved Domains (1) summary
      cl25703
      Location:2568
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    13. NM_001374689.1NP_001361618.1  protein O-mannosyl-transferase 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Conserved Domains (1) summary
      COG1928
      Location:6716
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    14. NM_001374690.1NP_001361619.1  protein O-mannosyl-transferase 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL358781
      UniProtKB/TrEMBL
      A0A1V1FTP4
      Conserved Domains (1) summary
      COG1928
      Location:14647
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    15. NM_001374691.1NP_001361620.1  protein O-mannosyl-transferase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS48045.1
      UniProtKB/TrEMBL
      B4DEA0
      Related
      ENSP00000503356.1, ENST00000679189.1
      Conserved Domains (1) summary
      COG1928
      Location:2603
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    16. NM_001374692.1NP_001361621.1  protein O-mannosyl-transferase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS48045.1
      UniProtKB/TrEMBL
      B4DEA0
      Conserved Domains (1) summary
      COG1928
      Location:2603
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    17. NM_001374693.1NP_001361622.1  protein O-mannosyl-transferase 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS94517.1
      UniProtKB/TrEMBL
      A0A1V1FTP4, A0A7I2V445
      Related
      ENSP00000503552.1, ENST00000677626.1
      Conserved Domains (1) summary
      COG1928
      Location:6603
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    18. NM_001374695.1NP_001361624.1  protein O-mannosyl-transferase 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL358781
      UniProtKB/TrEMBL
      B4DSA5
      Conserved Domains (1) summary
      COG1928
      Location:2590
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    19. NM_001411024.1NP_001397953.1  protein O-mannosyl-transferase 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS94519.1
      UniProtKB/TrEMBL
      Q5JT02
      Related
      ENSP00000361294.5, ENST00000372220.5
    20. NM_007171.4NP_009102.4  protein O-mannosyl-transferase 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Consensus CDS
      CCDS6943.1
      UniProtKB/Swiss-Prot
      B3KQG0, B4DIF0, Q5JT01, Q5JT06, Q5JT08, Q8NC91, Q8TCA9, Q9NX32, Q9NX82, Q9UNT2, Q9Y6A1
      UniProtKB/TrEMBL
      A0A1V1FTP4
      Related
      ENSP00000361302.3, ENST00000372228.9
      Conserved Domains (1) summary
      COG1928
      Location:14742
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_148391.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
    2. NR_148392.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
    3. NR_148393.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
    4. NR_148394.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Related
      ENST00000678833.1
    5. NR_148395.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Related
      ENST00000679111.1
    6. NR_148396.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
    7. NR_148397.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Related
      ENST00000677099.1
    8. NR_148398.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Related
      ENST00000677853.1
    9. NR_148399.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
    10. NR_148400.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL358781
      Related
      ENST00000678626.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      131502918..131523799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518140.3XP_011516442.1  protein O-mannosyl-transferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A1V1FTP4
      Conserved Domains (4) summary
      smart00472
      Location:272329
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      COG1928
      Location:14693
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
      pfam02366
      Location:20240
      PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
      pfam16192
      Location:493691
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    2. XM_011518141.3XP_011516443.1  protein O-mannosyl-transferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A1V1FTP4
      Conserved Domains (4) summary
      smart00472
      Location:250307
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      COG1928
      Location:14671
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
      pfam02366
      Location:20218
      PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
      pfam16192
      Location:471669
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    3. XM_011518143.3XP_011516445.1  protein O-mannosyl-transferase 1 isoform X4

      Conserved Domains (2) summary
      smart00472
      Location:287344
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      pfam16192
      Location:437635
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    4. XM_011518142.3XP_011516444.1  protein O-mannosyl-transferase 1 isoform X3

      UniProtKB/TrEMBL
      B4DSA5
      Conserved Domains (4) summary
      smart00472
      Location:218275
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      COG1928
      Location:6639
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
      pfam02366
      Location:1186
      PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
      pfam16192
      Location:439637
      PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase
    5. XM_047422640.1XP_047278596.1  protein O-mannosyl-transferase 1 isoform X5

    6. XM_011518145.3XP_011516447.1  protein O-mannosyl-transferase 1 isoform X7

      UniProtKB/TrEMBL
      B4DSA5
      Conserved Domains (1) summary
      COG1928
      Location:2590
      PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    7. XM_047422641.1XP_047278597.1  protein O-mannosyl-transferase 1 isoform X6

    8. XM_047422642.1XP_047278598.1  protein O-mannosyl-transferase 1 isoform X8

    RNA

    1. XR_001746160.3 RNA Sequence

    2. XR_007061226.1 RNA Sequence

    3. XR_007061227.1 RNA Sequence

    4. XR_007061228.1 RNA Sequence

    5. XR_007061229.1 RNA Sequence

    6. XR_007061230.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      143715812..143736761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361759.1XP_054217734.1  protein O-mannosyl-transferase 1 isoform X1

    2. XM_054361760.1XP_054217735.1  protein O-mannosyl-transferase 1 isoform X2

    3. XM_054361762.1XP_054217737.1  protein O-mannosyl-transferase 1 isoform X4

    4. XM_054361761.1XP_054217736.1  protein O-mannosyl-transferase 1 isoform X3

    5. XM_054361763.1XP_054217738.1  protein O-mannosyl-transferase 1 isoform X5

    6. XM_054361765.1XP_054217740.1  protein O-mannosyl-transferase 1 isoform X7

    7. XM_054361764.1XP_054217739.1  protein O-mannosyl-transferase 1 isoform X6

    8. XM_054361766.1XP_054217741.1  protein O-mannosyl-transferase 1 isoform X8

    RNA

    1. XR_008487925.1 RNA Sequence

    2. XR_008487926.1 RNA Sequence

    3. XR_008487927.1 RNA Sequence

    4. XR_008487928.1 RNA Sequence

    5. XR_008487929.1 RNA Sequence

    6. XR_008487930.1 RNA Sequence