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    Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 105837, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mtbpprovided by MGI
    Official Full Name
    Mdm2, transformed 3T3 cell double minute p53 binding proteinprovided by MGI
    Primary source
    MGI:MGI:2146005
    See related
    Ensembl:ENSMUSG00000022369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDM2B; MDM2BP; AI429604
    Expression
    Broad expression in CNS E11.5 (RPKM 5.1), limb E14.5 (RPKM 4.4) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtbp in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (55420800..55489819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55557404..55626423)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (55388963..55457978)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type XIV, alpha 1 Neighboring gene predicted gene, 18787 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene syntrophin, basic 1 Neighboring gene predicted gene, 46516

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mdm2-binding protein
    Names
    mMTBP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168250.1NP_001161722.1  mdm2-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001161722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC123682, AK133855, BB615361
      Consensus CDS
      CCDS49609.1
      UniProtKB/Swiss-Prot
      Q8BJS8
      Related
      ENSMUSP00000129396.2, ENSMUST00000170046.8
      Conserved Domains (2) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:287622
      MTBP_mid; MDM2-binding
    2. NM_134092.3NP_598853.3  mdm2-binding protein isoform 1

      See identical proteins and their annotated locations for NP_598853.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC123682, AK133855, BB615361, BC038684
      Consensus CDS
      CCDS27478.1
      UniProtKB/Swiss-Prot
      Q8BJS8
      Related
      ENSMUSP00000022998.8, ENSMUST00000022998.14
      Conserved Domains (3) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:287626
      MTBP_mid; MDM2-binding
      pfam14920
      Location:630884
      MTBP_C; MDM2-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      55420800..55489819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245394.2XP_011243696.1  mdm2-binding protein isoform X1

      Conserved Domains (2) summary
      pfam14918
      Location:1270
      MTBP_N; MDM2-binding
      pfam14919
      Location:287622
      MTBP_mid; MDM2-binding
    2. XM_006520250.3XP_006520313.1  mdm2-binding protein isoform X2

      Conserved Domains (2) summary
      pfam14919
      Location:1296
      MTBP_mid; MDM2-binding
      pfam14920
      Location:300554
      MTBP_C; MDM2-binding
    3. XM_017316360.3XP_017171849.1  mdm2-binding protein isoform X2

      Conserved Domains (2) summary
      pfam14919
      Location:1296
      MTBP_mid; MDM2-binding
      pfam14920
      Location:300554
      MTBP_C; MDM2-binding
    4. XM_017316361.3XP_017171850.1  mdm2-binding protein isoform X3

      Related
      ENSMUSP00000128615.2, ENSMUST00000169667.2
      Conserved Domains (2) summary
      pfam14919
      Location:2225
      MTBP_mid; MDM2-binding
      pfam14920
      Location:229483
      MTBP_C; MDM2-binding

    RNA

    1. XR_004938781.1 RNA Sequence

    2. XR_383964.2 RNA Sequence

    3. XR_875211.2 RNA Sequence

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