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    Sgsm3 small G protein signaling modulator 3 [ Mus musculus (house mouse) ]

    Gene ID: 105835, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sgsm3provided by MGI
    Official Full Name
    small G protein signaling modulator 3provided by MGI
    Primary source
    MGI:MGI:1916329
    See related
    Ensembl:ENSMUSG00000042303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIP; Cip85; RUSC3; Rutbc; R75178; Rutbc3; AI428557; BB175482; 1810012I01Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 44.3), testis adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sgsm3 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80861966..80896491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80977762..81012290)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (80808195..80842720)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing 6b Neighboring gene microRNA 5113 Neighboring gene predicted gene 6612 Neighboring gene adenylosuccinate lyase Neighboring gene myocardin related transcription factor A Neighboring gene predicted gene, 25131 Neighboring gene RIKEN cDNA 4930483J18 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GTPase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small G protein signaling modulator 3
    Names
    Cx43-interacting protein of 85-kDa
    RUN and TBC1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357669.1NP_001344598.1  small G protein signaling modulator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141880
      Conserved Domains (3) summary
      cd11813
      Location:409461
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:114320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:488639
      RUN; RUN domain
    2. NM_134091.2NP_598852.3  small G protein signaling modulator 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI844026, AK142314, BC018197, BY242851
      Consensus CDS
      CCDS49673.2
      UniProtKB/Swiss-Prot
      Q8VCZ6
      Related
      ENSMUSP00000122543.2, ENSMUST00000139517.9
      Conserved Domains (3) summary
      cd11813
      Location:484536
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:114325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:563717
      RUN; RUN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      80861966..80896491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520249.5XP_006520312.1  small G protein signaling modulator 3 isoform X3

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574725
      RUN; RUN domain
    2. XM_006520244.5XP_006520307.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520307.1

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574725
      RUN; RUN domain
    3. XM_030248261.2XP_030104121.1  small G protein signaling modulator 3 isoform X4

      Conserved Domains (3) summary
      cd11813
      Location:494546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573724
      RUN; RUN domain
    4. XM_017316358.3XP_017171847.1  small G protein signaling modulator 3 isoform X5

      Conserved Domains (3) summary
      cd11813
      Location:318370
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      pfam00566
      Location:11159
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam02759
      Location:397548
      RUN; RUN domain
    5. XM_006520245.5XP_006520308.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520308.1

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574725
      RUN; RUN domain
    6. XM_006520247.5XP_006520310.1  small G protein signaling modulator 3 isoform X2

      See identical proteins and their annotated locations for XP_006520310.1

      Related
      ENSMUSP00000155794.2, ENSMUST00000124845.9
      Conserved Domains (3) summary
      cd11813
      Location:494546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573724
      RUN; RUN domain
    7. XM_006520246.5XP_006520309.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520309.1

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574725
      RUN; RUN domain
    8. XM_006520248.5XP_006520311.1  small G protein signaling modulator 3 isoform X2

      See identical proteins and their annotated locations for XP_006520311.1

      Conserved Domains (3) summary
      cd11813
      Location:494546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573724
      RUN; RUN domain
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