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    Sgsm3 small G protein signaling modulator 3 [ Mus musculus (house mouse) ]

    Gene ID: 105835, updated on 23-May-2018

    Summary

    Official Symbol
    Sgsm3provided by MGI
    Official Full Name
    small G protein signaling modulator 3provided by MGI
    Primary source
    MGI:MGI:1916329
    See related
    Ensembl:ENSMUSG00000042303 Vega:OTTMUSG00000034072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cip85; RUSC3; R75178; Rutbc3; AI428557; BB175482; 1810012I01Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 44.3), testis adult (RPKM 20.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sgsm3 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (80977765..81012290)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (80808195..80842720)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing 6b Neighboring gene microRNA 5113 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 pseudogene Neighboring gene adenylosuccinate lyase Neighboring gene myocardial related transcription factor A Neighboring gene RIKEN cDNA 4930483J18 gene Neighboring gene predicted gene, 31608

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTPase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small G protein signaling modulator 3
    Names
    Cx43-interacting protein of 85-kDa
    RUN and TBC1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357669.1NP_001344598.1  small G protein signaling modulator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141880
      Conserved Domains (3) summary
      cd11813
      Location:409461
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:114320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:488639
      RUN; RUN domain
    2. NM_134091.2NP_598852.3  small G protein signaling modulator 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI844026, AK142314, BC018197, BY242851
      Consensus CDS
      CCDS49673.2
      UniProtKB/Swiss-Prot
      Q8VCZ6
      Related
      ENSMUSP00000122543.1, OTTMUSP00000046552, ENSMUST00000139517.8, OTTMUST00000086075
      Conserved Domains (3) summary
      cd11813
      Location:484536
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:114325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:563717
      RUN; RUN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      80977765..81012290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520249.3XP_006520312.1  small G protein signaling modulator 3 isoform X3

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574728
      RUN; RUN domain
    2. XM_006520244.3XP_006520307.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520307.1

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574728
      RUN; RUN domain
    3. XM_006520245.3XP_006520308.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520308.1

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574728
      RUN; RUN domain
    4. XM_006520247.3XP_006520310.1  small G protein signaling modulator 3 isoform X2

      See identical proteins and their annotated locations for XP_006520310.1

      Conserved Domains (3) summary
      cd11813
      Location:494546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573727
      RUN; RUN domain
    5. XM_006520246.3XP_006520309.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520309.1

      Conserved Domains (3) summary
      cd11813
      Location:495547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574728
      RUN; RUN domain
    6. XM_006520248.3XP_006520311.1  small G protein signaling modulator 3 isoform X2

      See identical proteins and their annotated locations for XP_006520311.1

      Conserved Domains (3) summary
      cd11813
      Location:494546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573727
      RUN; RUN domain
    7. XM_017316358.1XP_017171847.1  small G protein signaling modulator 3 isoform X4

      Related
      ENSMUSP00000155794.1, ENSMUST00000124845.8
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