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    CCT4 chaperonin containing TCP1 subunit 4 [ Homo sapiens (human) ]

    Gene ID: 10575, updated on 5-Aug-2018

    Summary

    Official Symbol
    CCT4provided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:1617
    See related
    Ensembl:ENSG00000115484 MIM:605142; Vega:OTTHUMG00000152166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRB; Cctd; CCT-DELTA
    Summary
    The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See CCT4 in Genome Data Viewer
    Location:
    2p15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (61868127..61888671, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (62095262..62115806, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene serine and arginine repetitive matrix 1 pseudogene Neighboring gene ribosomal protein L31 pseudogene 30 Neighboring gene copper metabolism domain containing 1 Neighboring gene uncharacterized LOC107985768 Neighboring gene ribosomal protein SA pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Stimulator of TAR RNA-binding proteins (SRB) stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between SRB and HIV-1 Tat PubMed
    Vif vif HIV-1 Vif interacts with CCT4 PubMed
    integrase gag-pol Interaction of human CCT4 with HIV-1 integrase is presumed based on a reported binding interaction between yeast CCT4 and integrase PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126164, MGC126165

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperonin-containing T-complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    zona pellucida receptor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit delta
    Names
    TCP-1-delta
    chaperonin containing TCP1, subunit 4 (delta)
    chaperonin containing t-complex polypeptide 1, delta subunit
    stimulator of TAR RNA-binding

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256721.1NP_001243650.1  T-complex protein 1 subunit delta isoform b

      See identical proteins and their annotated locations for NP_001243650.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AA136129, AI439570, AK303082, BM765256, DB461009
      Consensus CDS
      CCDS58711.1
      UniProtKB/Swiss-Prot
      P50991
      Related
      ENSP00000443061.1, ENST00000544079.2
      Conserved Domains (1) summary
      cd03338
      Location:25508
      TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    2. NM_006430.3NP_006421.2  T-complex protein 1 subunit delta isoform a

      See identical proteins and their annotated locations for NP_006421.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (a).
      Source sequence(s)
      AI439570, BC106934, DB461009
      Consensus CDS
      CCDS33206.1
      UniProtKB/Swiss-Prot
      P50991
      Related
      ENSP00000377958.3, OTTHUMP00000201357, ENST00000394440.7, OTTHUMT00000325548
      Conserved Domains (1) summary
      cd03338
      Location:25538
      TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      61868127..61888671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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