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    CCT4 chaperonin containing TCP1 subunit 4 [ Homo sapiens (human) ]

    Gene ID: 10575, updated on 5-May-2024

    Summary

    Official Symbol
    CCT4provided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:1617
    See related
    Ensembl:ENSG00000115484 MIM:605142; AllianceGenome:HGNC:1617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRB; Cctd; CCT-DELTA
    Summary
    The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2p15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (61868085..61888671, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (61874246..61894829, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (62095220..62115806, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11532 Neighboring gene serine and arginine repetitive matrix 1 pseudogene Neighboring gene ribosomal protein L31 pseudogene 30 Neighboring gene uncharacterized LOC124907773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:62114819-62115380 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:62115381-62115940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:62116501-62117060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15843 Neighboring gene copper metabolism domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:62144288-62144788 Neighboring gene uncharacterized LOC124906012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15846 Neighboring gene MPRA-validated peak3724 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15848 Neighboring gene ribosomal protein SA pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify chaperonin containing TCP1 subunit 4 protein (CCT4), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Stimulator of TAR RNA-binding proteins (SRB) stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between SRB and HIV-1 Tat PubMed
    Vif vif HIV-1 Vif interacts with CCT4 PubMed
    integrase gag-pol Interaction of human CCT4 with HIV-1 integrase is presumed based on a reported binding interaction between yeast CCT4 and integrase PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126164, MGC126165

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chaperonin-containing T-complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of chaperonin-containing T-complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of zona pellucida receptor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit delta
    Names
    TCP-1-delta
    chaperonin containing TCP1, subunit 4 (delta)
    chaperonin containing t-complex polypeptide 1, delta subunit
    stimulator of TAR RNA-binding

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256721.1NP_001243650.1  T-complex protein 1 subunit delta isoform b

      See identical proteins and their annotated locations for NP_001243650.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AA136129, AI439570, AK303082, BM765256, DB461009
      Consensus CDS
      CCDS58711.1
      UniProtKB/TrEMBL
      A8K3C3
      Related
      ENSP00000443061.1, ENST00000544079.2
      Conserved Domains (1) summary
      cd03338
      Location:25508
      TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    2. NM_006430.4NP_006421.2  T-complex protein 1 subunit delta isoform a

      See identical proteins and their annotated locations for NP_006421.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (a).
      Source sequence(s)
      AC107081, AI439570, BC106934, DB461009
      Consensus CDS
      CCDS33206.1
      UniProtKB/Swiss-Prot
      B2R6I3, B7Z8B1, F5H5W3, O14870, P50991, Q53QP9, Q96C51
      UniProtKB/TrEMBL
      A8K3C3
      Related
      ENSP00000377958.3, ENST00000394440.8
      Conserved Domains (1) summary
      cd03338
      Location:25538
      TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      61868085..61888671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      61874246..61894829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)