Format

Send to:

Choose Destination
    • Showing Current items.

    CCT7 chaperonin containing TCP1 subunit 7 [ Homo sapiens (human) ]

    Gene ID: 10574, updated on 5-Aug-2018

    Summary

    Official Symbol
    CCT7provided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 7provided by HGNC
    Primary source
    HGNC:HGNC:1622
    See related
    Ensembl:ENSG00000135624 MIM:605140; Vega:OTTHUMG00000152765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCTH; CCTETA; NIP7-1; TCP1ETA
    Summary
    This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in testis (RPKM 102.9), adrenal (RPKM 73.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See CCT7 in Genome Data Viewer
    Location:
    2p13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (73233425..73253022)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73461364..73480150)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SMYD family member 5 Neighboring gene protease associated domain containing 1 Neighboring gene F-box protein 41 Neighboring gene early growth response 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CCT7 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with CCT7 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC110985

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperonin-containing T-complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zona pellucida receptor complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit eta
    Names
    CCT-eta
    HIV-1 Nef interacting protein
    TCP-1-eta
    chaperonin containing t-complex polypeptide 1, eta subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047121.1 RefSeqGene

      Range
      5812..24598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001009570.2NP_001009570.1  T-complex protein 1 subunit eta isoform b

      See identical proteins and their annotated locations for NP_001009570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment of the 5' coding region, compared to variant 1, resulting in a shorter isoform (b), compared to isoform a.
      Source sequence(s)
      AK098825, AK293597, CX781741, DC362157, DC395264
      Consensus CDS
      CCDS42696.1
      UniProtKB/Swiss-Prot
      Q99832
      Related
      ENSP00000381456.2, OTTHUMP00000213063, ENST00000398422.2, OTTHUMT00000327751
      Conserved Domains (1) summary
      cl02777
      Location:1321
      chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
    2. NM_001166284.1NP_001159756.1  T-complex protein 1 subunit eta isoform c

      See identical proteins and their annotated locations for NP_001159756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment of the 5' coding region, compared to variant 1, resulting in a shorter isoform (c), compared to isoform a.
      Source sequence(s)
      AK098825, AK298153, CX781741, DC362157, DC395264
      Consensus CDS
      CCDS54366.1
      UniProtKB/Swiss-Prot
      Q99832
      Related
      ENSP00000442058.1, ENST00000540468.5
      Conserved Domains (1) summary
      cd03340
      Location:3438
      TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
    3. NM_001166285.1NP_001159757.1  T-complex protein 1 subunit eta isoform d

      See identical proteins and their annotated locations for NP_001159757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate exon in its 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK098825, AK297846, CX781741, DC362157, DC395264
      Consensus CDS
      CCDS54367.1
      UniProtKB/Swiss-Prot
      Q99832
      Related
      ENSP00000437824.1, ENST00000539919.5
      Conserved Domains (1) summary
      cd03340
      Location:1481
      TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
    4. NM_006429.3NP_006420.1  T-complex protein 1 subunit eta isoform a

      See identical proteins and their annotated locations for NP_006420.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK098825, BC019296, CX781741, DC362157, DC395264
      Consensus CDS
      CCDS46336.1
      UniProtKB/Swiss-Prot
      Q99832
      Related
      ENSP00000258091.5, OTTHUMP00000202321, ENST00000258091.9, OTTHUMT00000327714
      Conserved Domains (1) summary
      cd03340
      Location:5525
      TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...

    RNA

    1. NR_029402.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK098825, AK293175, CX781741, DC362157, DC395264
    2. NR_029403.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon and uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK098825, AK302078, CX781741, DC362157, DC395264

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      73233425..73253022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532478.3XP_011530780.1  T-complex protein 1 subunit eta isoform X1

      See identical proteins and their annotated locations for XP_011530780.1

      UniProtKB/Swiss-Prot
      Q99832
      Conserved Domains (1) summary
      cd03340
      Location:1481
      TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
    2. XM_011532479.2XP_011530781.1  T-complex protein 1 subunit eta isoform X1

      See identical proteins and their annotated locations for XP_011530781.1

      UniProtKB/Swiss-Prot
      Q99832
      Conserved Domains (1) summary
      cd03340
      Location:1481
      TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
    Support Center