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    CEL carboxyl ester lipase [ Homo sapiens (human) ]

    Gene ID: 1056, updated on 8-Jul-2021

    Summary

    Official Symbol
    CELprovided by HGNC
    Official Full Name
    carboxyl ester lipaseprovided by HGNC
    Primary source
    HGNC:HGNC:1848
    See related
    Ensembl:ENSG00000170835 MIM:114840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8
    Summary
    The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward pancreas (RPKM 14647.9) See more
    Orthologs
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    Genomic context

    See CEL in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (133061981..133071861)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135937368..135947248)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376306 Neighboring gene general transcription factor IIIC subunit 5 Neighboring gene microRNA 6877 Neighboring gene carboxyl ester lipase pseudogene Neighboring gene ral guanine nucleotide dissociation stimulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Bile salt-stimulated lipase (BSSL) isolated from human milk binds to DC-SIGN, preventing HIV-1 gp120 from interacting with this receptor PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables hydrolase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sterol esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sterol esterase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables triglyceride lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables triglyceride lipase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intestinal cholesterol absorption NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intestinal lipid catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuron cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pancreatic juice secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in presynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein esterification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    bile salt-activated lipase
    Names
    bucelipase
    carboxyl ester hydrolase
    carboxyl ester lipase (bile salt-stimulated lipase)
    cholesterol esterase
    fetoacinar pancreatic protein
    lysophospholipase, pancreatic
    sterol esterase
    NP_001798.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016394.1 RefSeqGene

      Range
      5005..14884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001807.6NP_001798.3  bile salt-activated lipase precursor

      Status: REVIEWED

      Source sequence(s)
      AL162417
      Consensus CDS
      CCDS43896.1
      Related
      ENSP00000361151.6, ENST00000372080.8

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      133061981..133071861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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