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    Exoc5 exocyst complex component 5 [ Mus musculus (house mouse) ]

    Gene ID: 105504, updated on 18-Sep-2024

    Summary

    Official Symbol
    Exoc5provided by MGI
    Official Full Name
    exocyst complex component 5provided by MGI
    Primary source
    MGI:MGI:2145645
    See related
    Ensembl:ENSMUSG00000061244 AllianceGenome:MGI:2145645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm76; SEC10; PRO1912; Sec10l1
    Summary
    Enables protein N-terminus binding activity. Involved in protein localization to plasma membrane. Acts upstream of with a negative effect on epithelial cell apoptotic process. Acts upstream of or within establishment of planar polarity and non-motile cilium assembly. Predicted to be located in cytosol. Predicted to be part of exocyst. Used to study obstructive nephropathy. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.7), CNS E14 (RPKM 11.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Exoc5 in Genome Data Viewer
    Location:
    14 C1; 14 25.36 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49249379..49304124, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49011922..49066667, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36024 Neighboring gene STARR-seq mESC enhancer starr_36624 Neighboring gene predicted gene, 23470 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:49686153-49686414 Neighboring gene adaptor-related protein complex 5, mu 1 subunit Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of exocyst TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    exocyst complex component 5
    Names
    SEC10-like 1
    exocyst complex component Sec10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207214.3NP_997097.1  exocyst complex component 5

      See identical proteins and their annotated locations for NP_997097.1

      Status: VALIDATED

      Source sequence(s)
      AK134562, AK164067, AV025936, CT025618
      Consensus CDS
      CCDS49474.1
      UniProtKB/Swiss-Prot
      Q3TPX4, Q80VK3
      UniProtKB/TrEMBL
      Q3U8A5
      Related
      ENSMUSP00000125434.2, ENSMUST00000162175.9
      Conserved Domains (1) summary
      pfam07393
      Location:89707
      Sec10; Exocyst complex component Sec10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      49249379..49304124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315766.2XP_017171255.1  exocyst complex component 5 isoform X3

      UniProtKB/TrEMBL
      Q3U8A5
      Conserved Domains (2) summary
      pfam07393
      Location:89660
      Sec10; Exocyst complex component Sec10
      pfam10267
      Location:2584
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    2. XM_011244884.4XP_011243186.1  exocyst complex component 5 isoform X2

      UniProtKB/TrEMBL
      Q3U8A5
      Conserved Domains (2) summary
      pfam07393
      Location:89675
      Sec10; Exocyst complex component Sec10
      pfam10267
      Location:2584
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    3. XM_011244883.4XP_011243185.1  exocyst complex component 5 isoform X1

      UniProtKB/TrEMBL
      Q3U8A5
      Conserved Domains (2) summary
      pfam07393
      Location:89714
      Sec10; Exocyst complex component Sec10
      pfam10267
      Location:2584
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    4. XM_036158363.1XP_036014256.1  exocyst complex component 5 isoform X4

      Conserved Domains (1) summary
      pfam07393
      Location:89432
      Sec10; Exocyst complex component Sec10

    RNA

    1. XR_001781081.3 RNA Sequence