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    Slf1 SMC5-SMC6 complex localization factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 105377, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slf1provided by MGI
    Official Full Name
    SMC5-SMC6 complex localization factor 1provided by MGI
    Primary source
    MGI:MGI:2145448
    See related
    Ensembl:ENSMUSG00000021597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankr; Brct; Brctd; Brctx; Brctd1; Ankrd32; AW545819; 2700017A04Rik; C730024G01Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 4.5), CNS E18 (RPKM 4.5) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Slf1 in Genome Data Viewer
    Location:
    13; 13 C1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (77191207..77283632, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (77043088..77135513, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (77182349..77274729, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene multiple C2 domains, transmembrane 1 Neighboring gene VISTA enhancer mm1556 Neighboring gene chromatin modifying protein 2A pseudogene Neighboring gene RIKEN cDNA 2210408I21 gene Neighboring gene 60S ribosomal protein L17-like Neighboring gene VISTA enhancer mm881 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102362, MGC117761

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SMC5-SMC6 complex localization factor protein 1
    Names
    BRCT domain containing 1
    BRCT domain-containing protein 1
    ankyrin repeat domain 32
    ankyrin repeat domain-containing protein 32
    protein BRCTx

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134071.3NP_598832.3  SMC5-SMC6 complex localization factor protein 1

      See identical proteins and their annotated locations for NP_598832.3

      Status: VALIDATED

      Source sequence(s)
      AC122418, AC161266
      Consensus CDS
      CCDS26657.2
      UniProtKB/Swiss-Prot
      Q8R3P9
      Related
      ENSMUSP00000118312.3, ENSMUST00000151524.9
      Conserved Domains (4) summary
      sd00045
      Location:803834
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:807894
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      77191207..77283632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244453.4XP_011242755.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011242755.1

      Conserved Domains (4) summary
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    2. XM_036157822.1XP_036013715.1  SMC5-SMC6 complex localization factor protein 1 isoform X9

      Conserved Domains (4) summary
      sd00045
      Location:707738
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:711798
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    3. XM_036157820.1XP_036013713.1  SMC5-SMC6 complex localization factor protein 1 isoform X6

      Conserved Domains (4) summary
      sd00045
      Location:755786
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:759846
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    4. XM_006517035.4XP_006517098.1  SMC5-SMC6 complex localization factor protein 1 isoform X3

      Conserved Domains (4) summary
      sd00045
      Location:809840
      ANK; ANK repeat [structural motif]
      cd17750
      Location:1391
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:813900
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:133204
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    5. XM_011244456.4XP_011242758.1  SMC5-SMC6 complex localization factor protein 1 isoform X7

      Conserved Domains (4) summary
      sd00045
      Location:713744
      ANK; ANK repeat [structural motif]
      cd17750
      Location:1391
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:717804
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:133204
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    6. XM_011244455.4XP_011242757.1  SMC5-SMC6 complex localization factor protein 1 isoform X5

      Conserved Domains (4) summary
      sd00045
      Location:761792
      ANK; ANK repeat [structural motif]
      cd17750
      Location:1391
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:765852
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:133204
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    7. XM_011244452.4XP_011242754.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

      Conserved Domains (4) summary
      sd00045
      Location:818849
      ANK; ANK repeat [structural motif]
      cd17750
      Location:1391
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:822909
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:133204
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    8. XM_017315352.3XP_017170841.1  SMC5-SMC6 complex localization factor protein 1 isoform X8

      Conserved Domains (3) summary
      sd00045
      Location:709740
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:713800
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:2495
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    9. XM_036157821.1XP_036013714.1  SMC5-SMC6 complex localization factor protein 1 isoform X6

      Conserved Domains (4) summary
      sd00045
      Location:755786
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:759846
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    10. XM_017315351.3XP_017170840.1  SMC5-SMC6 complex localization factor protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8R3P9
      Conserved Domains (4) summary
      sd00045
      Location:803834
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:807894
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    11. XM_011244454.4XP_011242756.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011242756.1

      Conserved Domains (4) summary
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    12. XM_036157818.1XP_036013711.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      Conserved Domains (4) summary
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    13. XM_036157819.1XP_036013712.1  SMC5-SMC6 complex localization factor protein 1 isoform X4

      Conserved Domains (4) summary
      sd00045
      Location:803834
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:807894
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    14. XM_017315350.3XP_017170839.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      Conserved Domains (4) summary
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
      cd17750
      Location:785
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      cl00038
      Location:127198
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    15. XM_017315353.1XP_017170842.1  SMC5-SMC6 complex localization factor protein 1 isoform X11

      Conserved Domains (2) summary
      sd00045
      Location:322353
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:326413
      Ank_2; Ankyrin repeats (3 copies)
    16. XM_011244457.4XP_011242759.1  SMC5-SMC6 complex localization factor protein 1 isoform X10

      Conserved Domains (2) summary
      cd17750
      Location:1391
      BRCT_SLF1; BRCT domain of SMC5-SMC6 complex localization factor protein 1 (SLF1) and similar proteins
      cl00038
      Location:133204
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
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