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    Slf1 SMC5-SMC6 complex localization factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 105377, updated on 31-Jan-2019

    Summary

    Official Symbol
    Slf1provided by MGI
    Official Full Name
    SMC5-SMC6 complex localization factor 1provided by MGI
    Primary source
    MGI:MGI:2145448
    See related
    Ensembl:ENSMUSG00000021597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brctx; Brctd1; Ankrd32; AW545819; 2700017A04Rik; C730024G01Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 4.5), CNS E18 (RPKM 4.5) and 23 other tissues See more
    Orthologs

    Genomic context

    See Slf1 in Genome Data Viewer
    Location:
    13; 13 C1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (77043088..77135509, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (77182349..77274729, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene multiple C2 domains, transmembrane 1 Neighboring gene jagunal homolog 1 pseudogene Neighboring gene chromatin modifying protein 2A pseudogene Neighboring gene RIKEN cDNA 2210408I21 gene Neighboring gene predicted gene, 29844 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102362, MGC117761

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SMC5-SMC6 complex localization factor protein 1
    Names
    BRCT domain containing 1
    BRCT domain-containing protein 1
    ankyrin repeat domain 32
    ankyrin repeat domain-containing protein 32
    protein BRCTx

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134071.3NP_598832.3  SMC5-SMC6 complex localization factor protein 1

      See identical proteins and their annotated locations for NP_598832.3

      Status: VALIDATED

      Source sequence(s)
      AC122418, AC161266
      Consensus CDS
      CCDS26657.2
      UniProtKB/Swiss-Prot
      Q8R3P9
      Related
      ENSMUSP00000118312.2, ENSMUST00000151524.8
      Conserved Domains (4) summary
      cd00027
      Location:1578
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:799920
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:807894
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:803834
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      77043088..77135509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315350.1XP_017170839.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      Conserved Domains (4) summary
      cd00027
      Location:1578
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:808929
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
    2. XM_017315352.1XP_017170841.1  SMC5-SMC6 complex localization factor protein 1 isoform X7

    3. XM_017315353.1XP_017170842.1  SMC5-SMC6 complex localization factor protein 1 isoform X9

    4. XM_011244453.2XP_011242755.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011242755.1

      Conserved Domains (4) summary
      cd00027
      Location:1578
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:808929
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
    5. XM_011244454.2XP_011242756.1  SMC5-SMC6 complex localization factor protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011242756.1

      Conserved Domains (4) summary
      cd00027
      Location:1578
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:808929
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:816903
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:812843
      ANK; ANK repeat [structural motif]
    6. XM_011244452.2XP_011242754.1  SMC5-SMC6 complex localization factor protein 1 isoform X1

      Conserved Domains (4) summary
      cd00027
      Location:2184
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:814935
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:822909
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:818849
      ANK; ANK repeat [structural motif]
    7. XM_017315351.1XP_017170840.1  SMC5-SMC6 complex localization factor protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8R3P9
      Conserved Domains (4) summary
      cd00027
      Location:1578
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:799920
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:807894
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:803834
      ANK; ANK repeat [structural motif]
    8. XM_011244455.2XP_011242757.1  SMC5-SMC6 complex localization factor protein 1 isoform X5

      Conserved Domains (4) summary
      cd00027
      Location:2184
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:757878
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:765852
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:761792
      ANK; ANK repeat [structural motif]
    9. XM_006517035.3XP_006517098.1  SMC5-SMC6 complex localization factor protein 1 isoform X3

      Conserved Domains (4) summary
      cd00027
      Location:2184
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:805926
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:813900
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:809840
      ANK; ANK repeat [structural motif]
    10. XM_011244456.2XP_011242758.1  SMC5-SMC6 complex localization factor protein 1 isoform X6

      Conserved Domains (4) summary
      cd00027
      Location:2184
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00204
      Location:709830
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:717804
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:713744
      ANK; ANK repeat [structural motif]
    11. XM_011244457.2XP_011242759.1  SMC5-SMC6 complex localization factor protein 1 isoform X8

      Conserved Domains (1) summary
      cd00027
      Location:2184
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
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