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    HYOU1 hypoxia up-regulated 1 [ Homo sapiens (human) ]

    Gene ID: 10525, updated on 26-Jul-2021

    Summary

    Official Symbol
    HYOU1provided by HGNC
    Official Full Name
    hypoxia up-regulated 1provided by HGNC
    Primary source
    HGNC:HGNC:16931
    See related
    Ensembl:ENSG00000149428 MIM:601746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMD59; Grp170; HSP12A; ORP150; GRP-170; ORP-150
    Summary
    The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Broad expression in thyroid (RPKM 93.3), testis (RPKM 55.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HYOU1 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119044187..119057205, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118914899..118927916, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene centrosomal AT-AC splicing factor Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene solute carrier family 37 member 4 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene hydroxymethylbilane synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with hypoxia up-regulated 1 (HYOU1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with HYOU1; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of hypoxia up-regulated 1 (HYOU1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ94899, FLJ97572, DKFZp686N08236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    hypoxia up-regulated protein 1
    Names
    150 kDa oxygen-regulated protein
    170 kDa glucose-regulated protein
    epididymis secretory sperm binding protein
    oxygen regulated protein (150kD)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130991.3NP_001124463.1  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_001124463.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AA580314, AK127324, AK299648, AK301514, BC072436, HY089857, U65785
      Consensus CDS
      CCDS8408.1
      UniProtKB/Swiss-Prot
      Q9Y4L1
      UniProtKB/TrEMBL
      B3KXH0, B7Z602, B7Z766, Q6IN67
      Conserved Domains (2) summary
      cl00478
      Location:593694
      LGT; Prolipoprotein diacylglyceryl transferase
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_006389.5NP_006380.1  hypoxia up-regulated protein 1 precursor

      See identical proteins and their annotated locations for NP_006380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA580314, AK127324, AK301514, BC072436, DC364982, HY089857, U65785
      Consensus CDS
      CCDS8408.1
      UniProtKB/Swiss-Prot
      Q9Y4L1
      UniProtKB/TrEMBL
      B3KXH0, B7Z766, Q6IN67
      Related
      ENSP00000480150.1, ENST00000617285.5
      Conserved Domains (2) summary
      cl00478
      Location:593694
      LGT; Prolipoprotein diacylglyceryl transferase
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      119044187..119057205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271392.4XP_005271449.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005271449.1

      Related
      ENSP00000498353.1, ENST00000652093.1
      Conserved Domains (3) summary
      PHA00666
      Location:601739
      PHA00666; putative protease
      pfam00012
      Location:35672
      HSP70; Hsp70 protein
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_005271393.3XP_005271450.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005271450.1

      Conserved Domains (3) summary
      PHA00666
      Location:601739
      PHA00666; putative protease
      pfam00012
      Location:35672
      HSP70; Hsp70 protein
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. XM_017017095.1XP_016872584.1  hypoxia up-regulated protein 1 isoform X1

      Conserved Domains (3) summary
      PHA00666
      Location:601739
      PHA00666; putative protease
      pfam00012
      Location:35672
      HSP70; Hsp70 protein
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. XM_017017097.1XP_016872586.1  hypoxia up-regulated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9Y4L1
      Conserved Domains (2) summary
      cl00478
      Location:593694
      LGT; Prolipoprotein diacylglyceryl transferase
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. XM_017017096.1XP_016872585.1  hypoxia up-regulated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9Y4L1
      Conserved Domains (2) summary
      cl00478
      Location:593694
      LGT; Prolipoprotein diacylglyceryl transferase
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    6. XM_005271394.3XP_005271451.1  hypoxia up-regulated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005271451.1

      Conserved Domains (3) summary
      PHA00666
      Location:601739
      PHA00666; putative protease
      pfam00012
      Location:35672
      HSP70; Hsp70 protein
      cl17037
      Location:36424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. XR_001747729.1 RNA Sequence

    2. XR_002957117.1 RNA Sequence

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_009646203.1 Reference GRCh38.p13 PATCHES

      Range
      65787..78804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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