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    Txndc5 thioredoxin domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 105245, updated on 17-Aug-2021

    Summary

    Official Symbol
    Txndc5provided by MGI
    Official Full Name
    thioredoxin domain containing 5provided by MGI
    Primary source
    MGI:MGI:2145316
    See related
    Ensembl:ENSMUSG00000038991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERp; PC-; ERp46; PC-TRP; AL022641
    Expression
    Ubiquitous expression in colon adult (RPKM 145.4), adrenal adult (RPKM 131.5) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Txndc5 in Genome Data Viewer
    Location:
    13; 13 A3.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38684242..38712800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38500266..38528824, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (38592144..38620329, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47990 Neighboring gene bone morphogenetic protein 6 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 5, muted

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    thioredoxin domain-containing protein 5
    Names
    ER protein 46
    endoplasmic reticulum protein ERp46
    endoplasmic reticulum resident protein 46
    plasma cell-specific thioredoxin-related protein
    thioredoxin-like protein p46

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289598.1NP_001276527.1  thioredoxin domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001276527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and represents translation initiation at an in-frame downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154747, AK136046, AK224956, AY243534
      Consensus CDS
      CCDS79178.1
      UniProtKB/Swiss-Prot
      Q91W90
      UniProtKB/TrEMBL
      A0A0R4J1Y7, Q3UWX1
      Related
      ENSMUSP00000124516.2, ENSMUST00000162075.8
      Conserved Domains (3) summary
      cd03005
      Location:82182
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:85323
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:256
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. NM_001289599.1NP_001276528.1  thioredoxin domain-containing protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and coding region and represents translation initiation at a novel AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK225017, AY243534
      Consensus CDS
      CCDS79179.1
      UniProtKB/Swiss-Prot
      Q91W90
      UniProtKB/TrEMBL
      E9PXX7
      Related
      ENSMUSP00000124401.2, ENSMUST00000160653.2
      Conserved Domains (3) summary
      cd03005
      Location:103203
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:2344
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:277
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    3. NM_145367.4NP_663342.3  thioredoxin domain-containing protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_663342.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK224971, AK225023, AY243534
      Consensus CDS
      CCDS26463.1
      UniProtKB/Swiss-Prot
      Q91W90
      UniProtKB/TrEMBL
      Q3TEE8
      Related
      ENSMUSP00000041839.9, ENSMUST00000035988.16
      Conserved Domains (2) summary
      cd03005
      Location:176276
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:52417
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38684242..38712800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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