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    Rnf44 ring finger protein 44 [ Mus musculus (house mouse) ]

    Gene ID: 105239, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf44provided by MGI
    Official Full Name
    ring finger protein 44provided by MGI
    Primary source
    MGI:MGI:2145310
    See related
    Ensembl:ENSMUSG00000034928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI854545; mKIAA1100
    Expression
    Ubiquitous expression in adrenal adult (RPKM 91.4), thymus adult (RPKM 80.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rnf44 in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54827212..54841889, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54679399..54694076, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (54780760..54795321, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene clathrin, light polypeptide (Lcb) Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene cadherin-related family member 2 Neighboring gene G protein-regulated inducer of neurite outgrowth 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146025.1NP_001139497.1  RING finger protein 44 isoform 1

      See identical proteins and their annotated locations for NP_001139497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK161651, BC017630, CF426263, CJ106658
      Consensus CDS
      CCDS49268.1
      UniProtKB/Swiss-Prot
      Q3UHJ8
      UniProtKB/TrEMBL
      E9PUC0
      Related
      ENSMUSP00000118474.2, ENSMUST00000125871.8
      Conserved Domains (1) summary
      cd16472
      Location:377421
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    2. NM_001146026.1NP_001139498.1  RING finger protein 44 isoform 2

      See identical proteins and their annotated locations for NP_001139498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK147349, BC017630, CF426263, CJ106658
      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      pfam13639
      Location:355396
      zf-RING_2; Ring finger domain
    3. NM_001146027.1NP_001139499.1  RING finger protein 44 isoform 3

      See identical proteins and their annotated locations for NP_001139499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a segment of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK147349, BB841172, BC017630, CF426263, CF728349
      Consensus CDS
      CCDS49267.1
      UniProtKB/Swiss-Prot
      Q3UHJ8
      Related
      ENSMUSP00000123198.2, ENSMUST00000150806.8
      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    4. NM_134064.2NP_598825.2  RING finger protein 44 isoform 4

      See identical proteins and their annotated locations for NP_598825.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a segment of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK160115, BC017630, CF426263, CJ106658
      Consensus CDS
      CCDS49266.1
      UniProtKB/Swiss-Prot
      Q3UHJ8
      Related
      ENSMUSP00000136732.2, ENSMUST00000177950.8
      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    RNA

    1. NR_027395.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an alternate 5' exon and an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that would inhibit the translation of the expected primary ORF, as found in variant 1. Translation of the upstream ORF would render this transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      BC017630, BY346776, CD349765, CF426263, CJ147978
    2. NR_027396.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an alternate 5' exon and alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that would inhibit the translation of the expected primary ORF, as found in variant 1. Translation of the upstream ORF would render this transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      BC017630, BY346776, CD349765, CF426263

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54827212..54841889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247093.1XP_030102953.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    2. XM_030247090.1XP_030102950.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    3. XM_030247097.2XP_030102957.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    4. XM_030247088.2XP_030102948.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    5. XM_006517019.5XP_006517082.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_006517082.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16472
      Location:377421
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    6. XM_006517020.3XP_006517083.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    7. XM_011244446.2XP_011242748.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_011242748.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16472
      Location:377421
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    8. XM_017315336.1XP_017170825.1  RING finger protein 44 isoform X3

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Related
      ENSMUSP00000114259.2, ENSMUST00000134862.8
      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    9. XM_030247099.1XP_030102959.1  RING finger protein 44 isoform X4

      Related
      ENSMUSP00000043974.10, ENSMUST00000037422.16
      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    10. XM_030247089.1XP_030102949.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    11. XM_030247096.2XP_030102956.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    12. XM_011244450.1XP_011242752.1  RING finger protein 44 isoform X3

      See identical proteins and their annotated locations for XP_011242752.1

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    13. XM_006517018.5XP_006517081.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_006517081.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16472
      Location:377421
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    14. XM_030247087.1XP_030102947.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    15. XM_011244447.1XP_011242749.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_011242749.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16472
      Location:377421
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    16. XM_030247095.2XP_030102955.1  RING finger protein 44 isoform X4

      Related
      ENSMUSP00000116850.2, ENSMUST00000128257.8
      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    17. XM_030247100.1XP_030102960.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    18. XM_030247092.1XP_030102952.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    19. XM_011244449.2XP_011242751.1  RING finger protein 44 isoform X3

      See identical proteins and their annotated locations for XP_011242751.1

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    20. XM_030247085.2XP_030102945.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    21. XM_030247091.1XP_030102951.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    22. XM_011244451.1XP_011242753.1  RING finger protein 44 isoform X4

      See identical proteins and their annotated locations for XP_011242753.1

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    23. XM_036157809.1XP_036013702.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    24. XM_030247098.1XP_030102958.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
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