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    SEC23B SEC23 homolog B, COPII coat complex component [ Homo sapiens (human) ]

    Gene ID: 10483, updated on 4-Jul-2021

    Summary

    Official Symbol
    SEC23Bprovided by HGNC
    Official Full Name
    SEC23 homolog B, COPII coat complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:10702
    See related
    Ensembl:ENSG00000101310 MIM:610512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CWS7; CDAII; CDAN2; CDA-II; HEMPAS; hSec23B
    Summary
    The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 28.7), testis (RPKM 16.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SEC23B in Genome Data Viewer
    Location:
    20p11.23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (18507548..18561415)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18488192..18542059)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RB binding protein 9, serine hydrolase Neighboring gene ribosomal protein S19 pseudogene 1 Neighboring gene small integral membrane protein 26 Neighboring gene Sharpr-MPRA regulatory region 13138

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein transport protein Sec23B
    Names
    SEC23 homolog B, coat complex II component
    SEC23-like protein B
    SEC23-related protein B
    transport protein SEC23B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016281.2 RefSeqGene

      Range
      5459..58934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1134

    mRNA and Protein(s)

    1. NM_001172745.3NP_001166216.1  protein transport protein Sec23B isoform 1

      See identical proteins and their annotated locations for NP_001166216.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR exon, as compared to variant 2. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AL121893, AL121900, BC005032, BC005404, DC351945
      Consensus CDS
      CCDS13137.1
      UniProtKB/Swiss-Prot
      Q15437
      Related
      ENSP00000366685.1, ENST00000377465.6
      Conserved Domains (1) summary
      PLN00162
      Location:12765
      PLN00162; transport protein sec23; Provisional
    2. NM_001172746.3NP_001166217.1  protein transport protein Sec23B isoform 2

      See identical proteins and their annotated locations for NP_001166217.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternative splice site and lacks an in-frame segment in the 5' CDS, as compared to variant 2. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK296270, AL121900, BC005032
      Consensus CDS
      CCDS86935.1
      Related
      ENSP00000496460.1, ENST00000643747.1
      Conserved Domains (6) summary
      cd11287
      Location:594714
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12747
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:123372
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:5897
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:506599
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:385488
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
    3. NM_006363.6NP_006354.2  protein transport protein Sec23B isoform 1

      See identical proteins and their annotated locations for NP_006354.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternative splice site and lacks a segment in the 5' UTR, as compared to variant 2. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      BC001151, BC095404, CA307855, X97065
      Consensus CDS
      CCDS13137.1
      UniProtKB/Swiss-Prot
      Q15437
      Related
      ENSP00000497473.1, ENST00000650089.1
      Conserved Domains (1) summary
      PLN00162
      Location:12765
      PLN00162; transport protein sec23; Provisional
    4. NM_032985.6NP_116780.1  protein transport protein Sec23B isoform 1

      See identical proteins and their annotated locations for NP_116780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      BC005032, BC095404, BM925053, CA307855, EC528189
      Consensus CDS
      CCDS13137.1
      UniProtKB/Swiss-Prot
      Q15437
      Related
      ENSP00000338844.3, ENST00000336714.8
      Conserved Domains (1) summary
      PLN00162
      Location:12765
      PLN00162; transport protein sec23; Provisional
    5. NM_032986.5NP_116781.1  protein transport protein Sec23B isoform 1

      See identical proteins and their annotated locations for NP_116781.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks a segment in the 5' UTR, as compared to variant 2. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AL540773, BC001151, BC095404, CA307855, DC401693
      Consensus CDS
      CCDS13137.1
      UniProtKB/Swiss-Prot
      Q15437
      Related
      ENSP00000262544.2, ENST00000262544.6
      Conserved Domains (1) summary
      PLN00162
      Location:12765
      PLN00162; transport protein sec23; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      18507548..18561415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027593.1XP_016883082.1  protein transport protein Sec23B isoform X1

      UniProtKB/Swiss-Prot
      Q15437
      Conserved Domains (1) summary
      PLN00162
      Location:12765
      PLN00162; transport protein sec23; Provisional
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