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    Fancm Fanconi anemia, complementation group M [ Mus musculus (house mouse) ]

    Gene ID: 104806, updated on 20-Jul-2021

    Summary

    Official Symbol
    Fancmprovided by MGI
    Official Full Name
    Fanconi anemia, complementation group Mprovided by MGI
    Primary source
    MGI:MGI:2442306
    See related
    Ensembl:ENSMUSG00000055884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI427100; D12Ertd364; D12Ertd364e; C730036B14Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.1), CNS E14 (RPKM 2.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Fancm in Genome Data Viewer
    Location:
    12 C1; 12 27.21 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (65120884..65178616)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (65074110..65131842)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (66176593..66233045)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970 Neighboring gene FK506 binding protein 3 Neighboring gene MIS18 binding protein 1 Neighboring gene predicted gene, 31063

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork reversal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in resolution of meiotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of FANCM-MHF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Fanconi anemia group M protein homolog
    Names
    ATP-dependent RNA helicase FANCM
    NP_001351376.1
    NP_849243.2
    XP_006515403.1
    XP_006515404.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364447.1NP_001351376.1  Fanconi anemia group M protein homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159621, AK173211
      Conserved Domains (2) summary
      pfam16783
      Location:128
      FANCM-MHF_bd; FANCM to MHF binding domain
      cl27383
      Location:10231258
      ERCC4; ERCC4 domain
    2. NM_178912.4NP_849243.2  Fanconi anemia group M protein homolog isoform 1

      See identical proteins and their annotated locations for NP_849243.2

      Status: VALIDATED

      Source sequence(s)
      AC159621, AK050306, AK050832, AK085388, AK173211
      Consensus CDS
      CCDS25941.1
      UniProtKB/Swiss-Prot
      Q8BGE5
      Related
      ENSMUSP00000054797.5, ENSMUST00000058889.5
      Conserved Domains (7) summary
      COG1111
      Location:71610
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      COG1948
      Location:17641999
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      cd00046
      Location:94236
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd12091
      Location:287401
      FANCM_ID; Insert domain of FANCM and related proteins
      pfam00271
      Location:457564
      Helicase_C; Helicase conserved C-terminal domain
      pfam02732
      Location:17831909
      ERCC4; ERCC4 domain
      pfam16783
      Location:657769
      FANCM-MHF_bd; FANCM to MHF binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      65120884..65178616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515341.4XP_006515404.1  Fanconi anemia group M protein homolog isoform X2

      Conserved Domains (4) summary
      COG1111
      Location:71529
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      COG1948
      Location:16951930
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      cd18033
      Location:77258
      DEXDc_FANCM; DEAH-box helicase domain of FANCM
      pfam16783
      Location:588700
      FANCM-MHF_bd; FANCM to MHF binding domain
    2. XM_006515340.5XP_006515403.1  Fanconi anemia group M protein homolog isoform X1

      Conserved Domains (3) summary
      COG1111
      Location:71610
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      COG1948
      Location:17201955
      MUS81; ERCC4-type nuclease [Replication, recombination and repair]
      pfam16783
      Location:657769
      FANCM-MHF_bd; FANCM to MHF binding domain
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