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    HMGN4 high mobility group nucleosomal binding domain 4 [ Homo sapiens (human) ]

    Gene ID: 10473, updated on 9-Jun-2024

    Summary

    Official Symbol
    HMGN4provided by HGNC
    Official Full Name
    high mobility group nucleosomal binding domain 4provided by HGNC
    Primary source
    HGNC:HGNC:4989
    See related
    Ensembl:ENSG00000182952 AllianceGenome:HGNC:4989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NHC; HMG17L3
    Summary
    The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in lymph node (RPKM 30.6), thyroid (RPKM 30.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HMGN4 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26538366..26546933)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26406761..26415326)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26538594..26547161)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:26537578-26537871 Neighboring gene tRNA-Arg (anticodon ACG) 1-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17013 Neighboring gene tRNA-Val (anticodon CAC) 1-6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26549364-26550318 Neighboring gene HMGN4-LOC105374988 intergenic CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24247 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1175 Neighboring gene tRNA-Ala (anticodon CGC) 1-1 Neighboring gene tRNA-Ile (anticodon AAT) 5-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC5145

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleosomal DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    high mobility group nucleosome-binding domain-containing protein 4
    Names
    high mobility group protein N4
    high-mobility group (nonhistone chromosomal) protein 17-like 3
    high-mobility group protein 17-like 3
    non-histone chromosomal protein HMG-17-like 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006353.3NP_006344.1  high mobility group nucleosome-binding domain-containing protein 4

      See identical proteins and their annotated locations for NP_006344.1

      Status: REVIEWED

      Source sequence(s)
      AL121936
      Consensus CDS
      CCDS4615.1
      UniProtKB/Swiss-Prot
      B2R4I6, O00479, Q53XL9
      Related
      ENSP00000366798.1, ENST00000377575.3
      Conserved Domains (1) summary
      pfam01101
      Location:188
      HMG14_17; HMG14 and HMG17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26538366..26546933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791780.1 Reference GRCh38.p14 PATCHES

      Range
      84546..93113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26406761..26415326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)