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    Tsr1 TSR1 20S rRNA accumulation [ Mus musculus (house mouse) ]

    Gene ID: 104662, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tsr1provided by MGI
    Official Full Name
    TSR1 20S rRNA accumulationprovided by MGI
    Primary source
    MGI:MGI:2144566
    See related
    Ensembl:ENSMUSG00000038335 AllianceGenome:MGI:2144566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1401
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Orthologous to human TSR1 (TSR1 ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 18.1), CNS E11.5 (RPKM 15.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tsr1 in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74788906..74800166)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74898080..74909340)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene max binding protein Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene serine racemase Neighboring gene STARR-seq mESC enhancer starr_29979 Neighboring gene predicted gene, 22733 Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74826503-74826738 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    pre-rRNA-processing protein TSR1 homolog
    Names
    TSR1, 20S rRNA accumulation, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177325.3NP_796299.2  pre-rRNA-processing protein TSR1 homolog

      See identical proteins and their annotated locations for NP_796299.2

      Status: VALIDATED

      Source sequence(s)
      AK129350, BF455129, CD547366
      Consensus CDS
      CCDS36225.1
      UniProtKB/Swiss-Prot
      Q3TMW6, Q3TRK6, Q3U4T2, Q3UYU4, Q3V3X8, Q5SWD9, Q6ZPR9, Q8K2F5
      Related
      ENSMUSP00000039027.8, ENSMUST00000045807.14
      Conserved Domains (5) summary
      smart00785
      Location:228309
      AARP2CN; AARP2CN (NUC121) domain
      COG5177
      Location:32774
      COG5177; Uncharacterized conserved protein [Function unknown]
      pfam04950
      Location:489772
      RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
      cl00388
      Location:455482
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl21455
      Location:140255
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74788906..74800166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)