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    COG5 component of oligomeric golgi complex 5 [ Homo sapiens (human) ]

    Gene ID: 10466, updated on 13-Aug-2022

    Summary

    Official Symbol
    COG5provided by HGNC
    Official Full Name
    component of oligomeric golgi complex 5provided by HGNC
    Primary source
    HGNC:HGNC:14857
    See related
    Ensembl:ENSG00000164597 MIM:606821; AllianceGenome:HGNC:14857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDG2I; GTC90; GOLTC1
    Summary
    The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See COG5 in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (107201372..107563920, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (108517426..108879966, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (106841817..107204365, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8060 Neighboring gene PRKAR2B antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12069 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene uncharacterized LOC124901720 Neighboring gene uncharacterized LOC124901721 Neighboring gene HMG-box transcription factor 1 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene G protein-coupled receptor 22 Neighboring gene DUS4L-BCAP29 readthrough Neighboring gene small nucleolar RNA U109 Neighboring gene dihydrouridine synthase 4 like Neighboring gene B cell receptor associated protein 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ41732, FLJ44289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Golgi transport complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Golgi transport complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 5
    Names
    13S golgi transport complex 1 90 kDa subunit
    COG complex subunit 5
    conserved oligomeric Golgi complex protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028095.2 RefSeqGene

      Range
      5001..367771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161520.2NP_001154992.2  conserved oligomeric Golgi complex subunit 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC004492, AK022835, AK314270, BC068540
      Consensus CDS
      CCDS55152.1
      Related
      ENSP00000377228.3, ENST00000393603.7
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
    2. NM_001379511.1NP_001366440.1  conserved oligomeric Golgi complex subunit 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
    3. NM_001379512.1NP_001366441.1  conserved oligomeric Golgi complex subunit 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
    4. NM_001379513.1NP_001366442.1  conserved oligomeric Golgi complex subunit 5 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
    5. NM_001379514.1NP_001366443.1  conserved oligomeric Golgi complex subunit 5 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
    6. NM_001379515.1NP_001366444.1  conserved oligomeric Golgi complex subunit 5 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492
      Conserved Domains (2) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
      cl00549
      Location:481559
      ABC_membrane; ABC transporter transmembrane region
    7. NM_001379516.1NP_001366445.1  conserved oligomeric Golgi complex subunit 5 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Conserved Domains (1) summary
      cl22951
      Location:3581
      Vps51; Vps51/Vps67
    8. NM_006348.5NP_006339.4  conserved oligomeric Golgi complex subunit 5 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Consensus CDS
      CCDS5742.1
      Related
      ENSP00000297135.4, ENST00000297135.9
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5
    9. NM_181733.4NP_859422.3  conserved oligomeric Golgi complex subunit 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC002381, AC004492, AC004855
      Consensus CDS
      CCDS5743.1
      Related
      ENSP00000334703.3, ENST00000347053.8
      Conserved Domains (1) summary
      pfam10392
      Location:35158
      COG5; Golgi transport complex subunit 5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      107201372..107563920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446634.2XP_024302402.2  conserved oligomeric Golgi complex subunit 5 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852930.1 Reference GRCh38.p14 PATCHES

      Range
      46894..409575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      108517426..108879966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)