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    Cnot6 CCR4-NOT transcription complex, subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 104625, updated on 3-Aug-2021

    Summary

    Official Symbol
    Cnot6provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 6provided by MGI
    Primary source
    MGI:MGI:2144529
    See related
    Ensembl:ENSMUSG00000020362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCR4
    Expression
    Broad expression in CNS E11.5 (RPKM 21.1), limb E14.5 (RPKM 17.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cnot6 in Genome Data Viewer
    Location:
    11; 11 B1.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49562324..49604227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49671497..49713401, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (49488200..49526212, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FMS-like tyrosine kinase 4 Neighboring gene secretoglobin, family 3A, member 1 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene predicted gene 12192 Neighboring gene predicted gene, 36411 Neighboring gene predicted gene, 36507 Neighboring gene glutamine fructose-6-phosphate transaminase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC98472, A230103N10Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 6
    Names
    carbon catabolite repressor protein 4 homolog
    cytoplasmic deadenylase
    NP_001277670.1
    NP_001350285.1
    NP_001350286.1
    NP_997649.1
    XP_006532004.1
    XP_006532005.1
    XP_017169703.1
    XP_036012101.1
    XP_036012102.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290741.2NP_001277670.1  CCR4-NOT transcription complex subunit 6 isoform 1

      See identical proteins and their annotated locations for NP_001277670.1

      Status: VALIDATED

      Source sequence(s)
      AK039164, AL606479, BB402523, BC062950, CF746424
      Consensus CDS
      CCDS70172.1
      UniProtKB/Swiss-Prot
      Q8K3P5
      Related
      ENSMUSP00000121239.2, ENSMUST00000145353.8
      Conserved Domains (3) summary
      cd10313
      Location:191540
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      COG4886
      Location:52159
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
    2. NM_001363356.1NP_001350285.1  CCR4-NOT transcription complex subunit 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606479
      Conserved Domains (3) summary
      cd10313
      Location:191540
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      COG4886
      Location:52158
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
    3. NM_001363357.1NP_001350286.1  CCR4-NOT transcription complex subunit 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606479
      Conserved Domains (3) summary
      cd10313
      Location:91440
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      sd00031
      Location:426
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:344
      LRR_4; Leucine Rich repeats (2 copies)
    4. NM_212484.2NP_997649.1  CCR4-NOT transcription complex subunit 6 isoform 2

      See identical proteins and their annotated locations for NP_997649.1

      Status: VALIDATED

      Source sequence(s)
      AK039164, BB402523, BC062950, BY741392
      Consensus CDS
      CCDS24621.1
      UniProtKB/Swiss-Prot
      Q8K3P5
      Related
      ENSMUSP00000020624.7, ENSMUST00000020624.7
      Conserved Domains (3) summary
      COG4886
      Location:52158
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
      cl00490
      Location:186535
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49562324..49604227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531942.3XP_006532005.1  CCR4-NOT transcription complex subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_006532005.1

      UniProtKB/Swiss-Prot
      Q8K3P5
      Conserved Domains (3) summary
      cd10313
      Location:191540
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      COG4886
      Location:52159
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
    2. XM_017314214.3XP_017169703.1  CCR4-NOT transcription complex subunit 6 isoform X3

      Conserved Domains (3) summary
      cd10313
      Location:96445
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      sd00031
      Location:426
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:344
      LRR_4; Leucine Rich repeats (2 copies)
    3. XM_036156209.1XP_036012102.1  CCR4-NOT transcription complex subunit 6 isoform X2

      Conserved Domains (3) summary
      COG4886
      Location:52158
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
      cl00490
      Location:186535
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    4. XM_006531941.5XP_006532004.1  CCR4-NOT transcription complex subunit 6 isoform X1

      See identical proteins and their annotated locations for XP_006532004.1

      UniProtKB/Swiss-Prot
      Q8K3P5
      Conserved Domains (3) summary
      cd10313
      Location:191540
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      COG4886
      Location:52159
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
    5. XM_036156208.1XP_036012101.1  CCR4-NOT transcription complex subunit 6 isoform X1

      Conserved Domains (3) summary
      cd10313
      Location:191540
      Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
      COG4886
      Location:52159
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:5375
      LRR_1; leucine-rich repeat [structural motif]
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