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    Ppp4r3b protein phosphatase 4 regulatory subunit 3B [ Mus musculus (house mouse) ]

    Gene ID: 104570, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ppp4r3bprovided by MGI
    Official Full Name
    protein phosphatase 4 regulatory subunit 3Bprovided by MGI
    Primary source
    MGI:MGI:2144474
    See related
    Ensembl:ENSMUSG00000020463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smek; Smek2; AW011752; AW557776; mKIAA1387
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E14 (RPKM 7.1) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ppp4r3b in Genome Data Viewer
    Location:
    11; 11 A3.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29118053..29170797)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29172976..29220797)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (29072907..29120797)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 5 Neighboring gene polyribonucleotide nucleotidyltransferase 1 Neighboring gene predicted gene, 51940 Neighboring gene cilia and flagella associated protein 36 Neighboring gene fibrillarin pseudogene Neighboring gene predicted gene, 23109

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1387

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 3B
    Names
    SMEK homolog 2, suppressor of mek1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363358.1NP_001350287.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX000351, BX294116
      Conserved Domains (2) summary
      pfam04802
      Location:168359
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    2. NM_001363359.1NP_001350288.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX000351, BX294116
      Conserved Domains (3) summary
      pfam08365
      Location:631668
      IGF2_C; Insulin-like growth factor II E-peptide
      pfam04802
      Location:168359
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    3. NM_001363360.1NP_001350289.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX000351, BX294116
      Conserved Domains (3) summary
      pfam08365
      Location:619656
      IGF2_C; Insulin-like growth factor II E-peptide
      pfam04802
      Location:168333
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    4. NM_001363361.1NP_001350290.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX000351, BX294116
      Conserved Domains (3) summary
      pfam08365
      Location:549586
      IGF2_C; Insulin-like growth factor II E-peptide
      pfam04802
      Location:168263
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    5. NM_001363362.1NP_001350291.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 6

      Status: VALIDATED

      Source sequence(s)
      BX000351, BX294116
      Related
      ENSMUSP00000099920.3, ENSMUST00000102856.9
      Conserved Domains (2) summary
      pfam04802
      Location:168359
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    6. NM_134034.3NP_598795.2  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform 1

      See identical proteins and their annotated locations for NP_598795.2

      Status: VALIDATED

      Source sequence(s)
      AK037253, AK133211, BE692419, CD350450
      Consensus CDS
      CCDS24492.1
      UniProtKB/Swiss-Prot
      Q922R5
      Related
      ENSMUSP00000020755.6, ENSMUST00000020755.12
      Conserved Domains (3) summary
      pfam04802
      Location:168359
      SMK-1; Component of IIS longevity pathway SMK-1
      pfam08365
      Location:645682
      IGF2_C; Insulin-like growth factor II E-peptide
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain

    RNA

    1. NR_156485.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX000351, BX294116

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      29118053..29170797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156203.1XP_036012096.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1

      Conserved Domains (2) summary
      pfam04802
      Location:168359
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    2. XM_036156204.1XP_036012097.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X2

      Conserved Domains (2) summary
      pfam04802
      Location:168359
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    3. XM_036156205.1XP_036012098.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X3

      Conserved Domains (2) summary
      pfam04802
      Location:168263
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    4. XM_036156206.1XP_036012099.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X4

      Conserved Domains (2) summary
      pfam04802
      Location:168263
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:765
      PH-like; Pleckstrin homology-like domain
    5. XM_036156207.1XP_036012100.1  serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X5

      Conserved Domains (1) summary
      pfam04802
      Location:1263
      SMK-1; Component of IIS longevity pathway SMK-1

    RNA

    1. XR_004936677.1 RNA Sequence

    2. XR_004936679.1 RNA Sequence

    3. XR_004936678.1 RNA Sequence

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