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    Rexo2 RNA exonuclease 2 [ Mus musculus (house mouse) ]

    Gene ID: 104444, updated on 23-May-2018

    Summary

    Official Symbol
    Rexo2provided by MGI
    Official Full Name
    RNA exonuclease 2provided by MGI
    Primary source
    MGI:MGI:1888981
    See related
    Ensembl:ENSMUSG00000032026 Vega:OTTMUSG00000063007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfn; Rex2; Smfn; AW107347; 1810038D15Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 86.0), liver E14 (RPKM 25.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rexo2 in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (48468512..48480713, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (48276619..48288716, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39335 Neighboring gene predicted gene 8884 Neighboring gene predicted gene, 39334 Neighboring gene RNA binding motif protein 7 Neighboring gene predicted gene 5617

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    nucleobase-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    oligoribonuclease, mitochondrial
    Names
    REX2, RNA exonuclease 2 homolog
    small fragment nuclease

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357501.2NP_001344430.1  oligoribonuclease, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC160992
      Conserved Domains (1) summary
      cd06135
      Location:46187
      Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
    2. NM_001357503.1NP_001344432.1  oligoribonuclease, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1.
      Source sequence(s)
      AC160992
      Conserved Domains (1) summary
      cl10012
      Location:39121
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    3. NM_001357505.1NP_001344434.1  oligoribonuclease, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC160992
      Conserved Domains (1) summary
      cl10012
      Location:39103
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    4. NM_024233.4NP_077195.2  oligoribonuclease, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_077195.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI839882, AK007731
      Consensus CDS
      CCDS23154.1
      UniProtKB/Swiss-Prot
      Q9D8S4
      Related
      ENSMUSP00000034524.3, OTTMUSP00000079382, ENSMUST00000034524.4
      Conserved Domains (1) summary
      cd06135
      Location:43215
      Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      48468512..48480713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509934.3XP_006509997.1  oligoribonuclease, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd06135
      Location:46187
      Orn; DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins
    2. XM_006509935.2XP_006509998.1  oligoribonuclease, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006509998.1

      UniProtKB/TrEMBL
      Q8BJ91
      Conserved Domains (1) summary
      cl10012
      Location:39104
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
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