Format

Send to:

Choose Destination
    • Showing Current items.

    Rcor2 REST corepressor 2 [ Mus musculus (house mouse) ]

    Gene ID: 104383, updated on 16-Oct-2021

    Summary

    Official Symbol
    Rcor2provided by MGI
    Official Full Name
    REST corepressor 2provided by MGI
    Primary source
    MGI:MGI:1859854
    See related
    Ensembl:ENSMUSG00000024968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1A13; Rcor; Rcor1; CoREST; AW122124
    Expression
    Biased expression in CNS E11.5 (RPKM 58.1), CNS E14 (RPKM 45.4) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rcor2 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7244759..7252590)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7267394..7275225)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (7344255..7349715)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene predicted gene, 22113 Neighboring gene MAP/microtubule affinity regulating kinase 2 Neighboring gene predicted gene 17227 Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene RIKEN cDNA 1700105P06 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    REST corepressor 2
    Names
    RE1-silencing transcription factor (REST) co-repressor 1
    REST co-repressor 2
    co-repressor of Rest

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320554.1NP_001307483.1  REST corepressor 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC055719, CJ165194
      Consensus CDS
      CCDS29522.2
      UniProtKB/Swiss-Prot
      Q8C796
      Related
      ENSMUSP00000063335.5, ENSMUST00000066646.12
      Conserved Domains (4) summary
      smart00717
      Location:331376
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:331374
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:4698
      ELM2; ELM2 domain
      cl21498
      Location:134178
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. NM_054048.4NP_473389.2  REST corepressor 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK052295, BC055719, BY198423
      Consensus CDS
      CCDS29522.2
      UniProtKB/Swiss-Prot
      Q8C796
      Related
      ENSMUSP00000108996.3, ENSMUST00000113369.3
      Conserved Domains (4) summary
      smart00717
      Location:331376
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:331374
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:4698
      ELM2; ELM2 domain
      cl21498
      Location:134178
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7244759..7252590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526551.3XP_006526614.1  REST corepressor 2 isoform X1

      Conserved Domains (4) summary
      PRK12323
      Location:399531
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam00249
      Location:340383
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:55107
      ELM2; ELM2 domain
      cl21498
      Location:143187
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. XM_030250677.1XP_030106537.1  REST corepressor 2 isoform X2

      Conserved Domains (2) summary
      PRK12323
      Location:216348
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam00249
      Location:157200
      Myb_DNA-binding; Myb-like DNA-binding domain
    Support Center