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    RBM14 RNA binding motif protein 14 [ Homo sapiens (human) ]

    Gene ID: 10432, updated on 5-May-2024

    Summary

    Official Symbol
    RBM14provided by HGNC
    Official Full Name
    RNA binding motif protein 14provided by HGNC
    Primary source
    HGNC:HGNC:14219
    See related
    Ensembl:ENSG00000239306 MIM:612409; AllianceGenome:HGNC:14219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP; COAA; PSP2; SYTIP1; TMEM137
    Summary
    This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]
    Annotation information
    Note: The nomenclature TMEM137, transmembrane protein 137 was assigned to BC024260, which is now thought to represent the 3' UTR of RBM14. [15 Aug 2008]
    Expression
    Ubiquitous expression in testis (RPKM 11.0), lymph node (RPKM 7.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBM14 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66616630..66629934)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66612875..66626179)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66384101..66397405)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5053 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66384051-66384984 Neighboring gene RBM14-RBM4 readthrough Neighboring gene RNA, U4 small nuclear 39, pseudogene Neighboring gene hESC enhancers GRCh37_chr11:66405625-66406338 and GRCh37_chr11:66406339-66407050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66410755-66411278 Neighboring gene MPRA-validated peak1306 silencer Neighboring gene RNA binding motif protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3600 Neighboring gene RNA binding motif protein 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66453249-66453749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66462288-66462788 Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene RNA, 7SL, cytoplasmic 12, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev The localization of RBM14 to the nuclear paraspeckles is required for RBM14 enhancement of HIV-1 Rev activity in cells PubMed
    rev Co-immunoprecipitation analysis demonstrates that endogenous RBM14 associates with HIV-1 Rev, XPO1, and p54/NRB in cells PubMed
    rev Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid PubMed
    Tat tat RNA binding motif protein 14 (RBM14) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    capsid gag Depletion of RBM14 inhibits HIV-1 Rev activity, leading to reduced HIV-1 p24 expression from the Rev-mediated reporter plasmid PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough RBM14-RBM4

    Readthrough gene: RBM14-RBM4, Included gene: RBM4

    Clone Names

    • MGC15912, MGC31756, DKFZp779J0927

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor coactivator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables splicing factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding protein 14
    Names
    RRM-containing coactivator activator/modulator
    SYT-interacting protein
    paraspeckle protein 2
    synaptotagmin-interacting protein
    transmembrane protein 137

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030394.1 RefSeqGene

      Range
      5049..18353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198836.2NP_001185765.1  RNA-binding protein 14 isoform 2

      See identical proteins and their annotated locations for NP_001185765.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (2, also known as CoAM or coactivator modulator) with a distinct and shorter C-terminus compared to isoform 1. This isoform lacks the TRBP-interacting domain, and functions as a transcriptional repressor by inhibiting the activity of isoform 1 (PMID:11443112).
      Source sequence(s)
      AF315633, AP001157
      Consensus CDS
      CCDS55772.1
      UniProtKB/TrEMBL
      A0A0S2Z567
      Related
      ENSP00000377548.3, ENST00000393979.3
      Conserved Domains (2) summary
      cd12609
      Location:79146
      RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)
      cl17169
      Location:171
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001198837.2NP_001185766.1  RNA-binding protein 14 isoform 3

      See identical proteins and their annotated locations for NP_001185766.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal coding exon compared to variant 1. This results in a frame-shift and an isoform (3, also known as CoAR or coactivator regulator) with a distinct and shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AP001157, DB044990, DQ294957
      Consensus CDS
      CCDS55773.1
      UniProtKB/TrEMBL
      A0A0S2Z5V2, F8WDX3
      Related
      ENSP00000386995.4, ENST00000409738.4
      Conserved Domains (1) summary
      cl17169
      Location:171
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_006328.4NP_006319.1  RNA-binding protein 14 isoform 1

      See identical proteins and their annotated locations for NP_006319.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CoAA or coactivator activator).
      Source sequence(s)
      AK021768, AP001157, DB044990
      Consensus CDS
      CCDS8147.1
      UniProtKB/Swiss-Prot
      B0LM41, B3KMN4, D6RGD8, O75932, Q2PYN1, Q53GV1, Q68DQ9, Q96PK5, Q96PK6
      UniProtKB/TrEMBL
      A0A0S2Z4Z0
      Related
      ENSP00000311747.5, ENST00000310137.5
      Conserved Domains (4) summary
      TIGR01628
      Location:3280
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      PRK13875
      Location:319433
      PRK13875; conjugal transfer protein TrbL; Provisional
      cd12608
      Location:171
      RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
      cd12609
      Location:79146
      RRM2_CoAA; RNA recognition motif 2 in vertebrate RRM-containing coactivator activator/modulator (CoAA)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66616630..66629934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66612875..66626179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032886.2: Suppressed sequence

      Description
      NM_032886.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.