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    Tex15 testis expressed gene 15 meiosis and synapsis associated [ Mus musculus (house mouse) ]

    Gene ID: 104271, updated on 3-Jun-2024

    Summary

    Official Symbol
    Tex15provided by MGI
    Official Full Name
    testis expressed gene 15 meiosis and synapsis associatedprovided by MGI
    Primary source
    MGI:MGI:1934816
    See related
    Ensembl:ENSMUSG00000009628 AllianceGenome:MGI:1934816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210014E14Rik
    Summary
    Involved in DNA methylation and negative regulation of transposition. Acts upstream of or within several processes, including male gamete generation; regulation of double-strand break repair via homologous recombination; and synaptonemal complex assembly. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 4.1), testis adult (RPKM 3.8) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tex15 in Genome Data Viewer
    Location:
    8 A4; 8 20.59 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34006712..34082531)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33516689..33592503)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21104 Neighboring gene STARR-seq mESC enhancer starr_21105 Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene Neighboring gene high mobility group box 1, related sequence 17 Neighboring gene STARR-seq mESC enhancer starr_21108 Neighboring gene STARR-seq mESC enhancer starr_21109 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene UBX domain protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect DNA methylation-dependent heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrotransposon silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    testis-expressed protein 15
    Names
    testis-expressed sequence 15 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031374.2NP_113551.2  testis-expressed protein 15

      See identical proteins and their annotated locations for NP_113551.2

      Status: VALIDATED

      Source sequence(s)
      AC139025, AF285589, BC063106
      Consensus CDS
      CCDS22232.1
      UniProtKB/Swiss-Prot
      F8VPN2, Q3UPQ6, Q3V162, Q99MV3
      Related
      ENSMUSP00000009772.8, ENSMUST00000009772.8
      Conserved Domains (1) summary
      pfam15326
      Location:15741788
      TEX15; Testis expressed sequence 15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      34006712..34082531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508976.4XP_006509039.1  testis-expressed protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006509039.1

      Conserved Domains (2) summary
      pfam12509
      Location:104251
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18482062
      TEX15; Testis expressed sequence 15
    2. XM_006508977.4XP_006509040.1  testis-expressed protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006509040.1

      Conserved Domains (2) summary
      pfam12509
      Location:104251
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18482062
      TEX15; Testis expressed sequence 15
    3. XM_006508975.3XP_006509038.1  testis-expressed protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006509038.1

      Conserved Domains (2) summary
      pfam12509
      Location:104251
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18482062
      TEX15; Testis expressed sequence 15
    4. XM_011242106.2XP_011240408.1  testis-expressed protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011240408.1

      Conserved Domains (2) summary
      pfam12509
      Location:104251
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18482062
      TEX15; Testis expressed sequence 15

    RNA

    1. XR_378774.2 RNA Sequence

    2. XR_004934745.1 RNA Sequence