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    PGRMC2 progesterone receptor membrane component 2 [ Homo sapiens (human) ]

    Gene ID: 10424, updated on 19-Jun-2024

    Summary

    Official Symbol
    PGRMC2provided by HGNC
    Official Full Name
    progesterone receptor membrane component 2provided by HGNC
    Primary source
    HGNC:HGNC:16089
    See related
    Ensembl:ENSG00000164040 MIM:607735; AllianceGenome:HGNC:16089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DG6; PMBP
    Summary
    Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 36.7), small intestine (RPKM 30.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PGRMC2 in Genome Data Viewer
    Location:
    4q28.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (128269242..128287813, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (131573342..131591912, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (129190397..129208968, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak5106 silencer Neighboring gene La ribonucleoprotein 1B Neighboring gene ribosomal protein L15 pseudogene 8 Neighboring gene FOSL1 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr4:129186588-129187089 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:129197563-129197760 Neighboring gene Sharpr-MPRA regulatory region 13521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15684 Neighboring gene Sharpr-MPRA regulatory region 12082 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:129242766-129243328 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:129271007-129271585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129271620-129272158 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:129283869-129284407 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:129308825-129310024 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73985 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_73994 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129337187-129337688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129337689-129338188 Neighboring gene long intergenic non-protein coding RNA 2615 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:129390695-129391894 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15685 Neighboring gene NFE2L2 motif-containing MPRA enhancer 199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129456135-129456788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129456789-129457442 Neighboring gene uncharacterized LOC101927259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21891

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of progesterone receptor membrane component 2 (PGRMC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of progesterone receptor membrane component 2 (PGRMC2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear steroid receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    membrane-associated progesterone receptor component 2
    Names
    progesterone membrane binding protein
    steroid receptor protein DG6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006320.6NP_006311.3  membrane-associated progesterone receptor component 2

      Status: VALIDATED

      Source sequence(s)
      AI375856, AK091741, AK131272
      Consensus CDS
      CCDS3739.3
      UniProtKB/Swiss-Prot
      O15173, Q569H1
      Related
      ENSP00000296425.4, ENST00000296425.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      128269242..128287813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      131573342..131591912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)