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    Acly ATP citrate lyase [ Mus musculus (house mouse) ]

    Gene ID: 104112, updated on 5-Sep-2021

    Summary

    Official Symbol
    Aclyprovided by MGI
    Official Full Name
    ATP citrate lyaseprovided by MGI
    Primary source
    MGI:MGI:103251
    See related
    Ensembl:ENSMUSG00000020917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW538652; A730098H14Rik
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 333.0), mammary gland adult (RPKM 298.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acly in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100367178..100418826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100476352..100528000, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100337670..100389215, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 10 Neighboring gene kelch-like 11 Neighboring gene microRNA 7116 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA) Neighboring gene outer dynein arm complex subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP citrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP citrate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP citrate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-citrate synthase
    Names
    ATP-citrate (pro-S-)-lyase
    citrate cleavage enzyme
    NP_001186225.1
    NP_598798.1
    XP_036012093.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199296.1NP_001186225.1  ATP-citrate synthase isoform 1

      See identical proteins and their annotated locations for NP_001186225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK132755, BE623317, BX842667
      Consensus CDS
      CCDS56807.1
      UniProtKB/TrEMBL
      Q3V117
      Related
      ENSMUSP00000103012.2, ENSMUST00000107389.8
      Conserved Domains (2) summary
      cl25712
      Location:1419
      SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
      cl26126
      Location:4891094
      Ligase_CoA; CoA-ligase
    2. NM_134037.3NP_598798.1  ATP-citrate synthase isoform 2

      See identical proteins and their annotated locations for NP_598798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the middle of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      BC056378, BE623317, BX842667
      Consensus CDS
      CCDS25425.1
      UniProtKB/Swiss-Prot
      Q91V92
      Related
      ENSMUSP00000007131.10, ENSMUST00000007131.16
      Conserved Domains (2) summary
      cl25712
      Location:1419
      SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]
      cl26126
      Location:4791084
      Ligase_CoA; CoA-ligase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100367178..100418826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156200.1XP_036012093.1  ATP-citrate synthase isoform X1

      Conserved Domains (1) summary
      PLN02522
      Location:1591
      PLN02522; ATP citrate (pro-S)-lyase
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