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    BASP1 brain abundant membrane attached signal protein 1 [ Homo sapiens (human) ]

    Gene ID: 10409, updated on 9-Jun-2024

    Summary

    Official Symbol
    BASP1provided by HGNC
    Official Full Name
    brain abundant membrane attached signal protein 1provided by HGNC
    Primary source
    HGNC:HGNC:957
    See related
    Ensembl:ENSG00000176788 MIM:605940; AllianceGenome:HGNC:957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP23; NAP22; CAP-23; NAP-22
    Summary
    This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]
    Expression
    Biased expression in brain (RPKM 144.2), prostate (RPKM 45.3) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BASP1 in Genome Data Viewer
    Location:
    5p15.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (17216823..17276834)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (17156199..17216216)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (17216932..17276943)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene BASP1 antisense RNA 1 Neighboring gene uncharacterized LOC105374664 Neighboring gene Sharpr-MPRA regulatory region 6771 Neighboring gene Sharpr-MPRA regulatory region 14227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15948 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:17218860-17219640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:17227689-17228189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22424 Neighboring gene RNA, U6 small nuclear 1003, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15951 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:17275743-17276243 Neighboring gene BASP1-FTH1P10 intergenic CAGE-defined low expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:17311529-17312170 Neighboring gene aurora kinase A interacting protein 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 14736 Neighboring gene RN7SK pseudogene 133

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of brain membrane attached signal protein 1 (BASP1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8555

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in diaphragm development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gonad development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mesenchymal to epithelial transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metanephric mesenchyme development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in podocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of heart growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of metanephric ureteric bud development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in substantia nigra development HEP PubMed 
    involved_in supramolecular fiber organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thorax and anterior abdomen determination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in vesicle HDA PubMed 

    General protein information

    Preferred Names
    brain acid soluble protein 1
    Names
    22 kDa neuronal tissue-enriched acidic protein
    brain acid-soluble protein 1
    neuronal axonal membrane protein NAP-22
    neuronal tissue-enriched acidic protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271606.2NP_001258535.1  brain acid soluble protein 1

      See identical proteins and their annotated locations for NP_001258535.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000518, BM973114, BU181147, DA489123, DW458407, HY258599
      Consensus CDS
      CCDS3888.1
      UniProtKB/Swiss-Prot
      B4DJA8, D3DTD5, O43596, P80723, Q5U0S0, Q9BWA5
      Related
      ENSP00000482066.1, ENST00000616743.1
      Conserved Domains (1) summary
      pfam05466
      Location:12227
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    2. NM_006317.5NP_006308.3  brain acid soluble protein 1

      See identical proteins and their annotated locations for NP_006308.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC000518, BM973114, BU181147, CN355202, HY258599
      Consensus CDS
      CCDS3888.1
      UniProtKB/Swiss-Prot
      B4DJA8, D3DTD5, O43596, P80723, Q5U0S0, Q9BWA5
      Related
      ENSP00000319281.3, ENST00000322611.4
      Conserved Domains (1) summary
      pfam05466
      Location:12227
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      17216823..17276834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      17156199..17216216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)