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    CPQ carboxypeptidase Q [ Homo sapiens (human) ]

    Gene ID: 10404, updated on 5-Mar-2024

    Summary

    Official Symbol
    CPQprovided by HGNC
    Official Full Name
    carboxypeptidase Qprovided by HGNC
    Primary source
    HGNC:HGNC:16910
    See related
    Ensembl:ENSG00000104324 MIM:618754; AllianceGenome:HGNC:16910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LDP; PGCP
    Summary
    This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in thyroid (RPKM 83.5), ovary (RPKM 28.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    8q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (96645242..97143501)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (97770966..98269215)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (97657470..98155729)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27665 Neighboring gene RNA, U6 small nuclear 1172, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5310 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:97532917-97533417 Neighboring gene uncharacterized LOC124900253 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:97563257-97563757 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:97592183-97592688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:97601754-97602254 Neighboring gene syndecan 2 Neighboring gene Sharpr-MPRA regulatory region 4348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:97731641-97732141 Neighboring gene uncharacterized LOC124901985 Neighboring gene uncharacterized LOC101927066 Neighboring gene uncharacterized LOC105375655 Neighboring gene Sharpr-MPRA regulatory region 10694 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:98217733-98218532 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:98218533-98219332 Neighboring gene Sharpr-MPRA regulatory region 2413 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:98226988-98227220 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:98244253-98244860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:98289193-98289694 Neighboring gene TSPY like 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of sleep habits and insomnia.
    EBI GWAS Catalog
    GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallodipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallodipeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thyroid hormone generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thyroid hormone generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tissue regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase Q
    Names
    Ser-Met dipeptidase
    aminopeptidase
    blood plasma glutamate carboxypeptidase
    lysosomal dipeptidase
    NP_057218.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016134.4NP_057218.1  carboxypeptidase Q preproprotein

      See identical proteins and their annotated locations for NP_057218.1

      Status: REVIEWED

      Source sequence(s)
      AA492294, AK315447, DA699663
      Consensus CDS
      CCDS6273.1
      UniProtKB/Swiss-Prot
      B2RD88, Q8NBZ1, Q9UNM8, Q9Y5X6, Q9Y646
      UniProtKB/TrEMBL
      B4DJC2
      Related
      ENSP00000220763.5, ENST00000220763.10
      Conserved Domains (2) summary
      cd03883
      Location:47449
      M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
      cd04815
      Location:130256
      PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      96645242..97143501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      97770966..98269215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)