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    RACK1 receptor for activated C kinase 1 [ Homo sapiens (human) ]

    Gene ID: 10399, updated on 7-Jul-2024

    Summary

    Official Symbol
    RACK1provided by HGNC
    Official Full Name
    receptor for activated C kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:4399
    See related
    Ensembl:ENSG00000204628 MIM:176981; AllianceGenome:HGNC:4399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H12.3; HLC-7; PIG21; GNB2L1; Gnb2-rs1
    Summary
    Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of cellular protein metabolic process; and regulation of signal transduction. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and phagocytic cup. Part of IRE1-RACK1-PP2A complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 1262.3), lymph node (RPKM 598.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RACK1 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181236897..181243906, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181796848..181803858, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180663897..180670906, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180651177-180652174 Neighboring gene microRNA 4638 Neighboring gene tripartite motif containing 41 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23792 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180672476-180673404 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180673405-180674331 Neighboring gene uncharacterized LOC101928649 Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:180674332-180675259 Neighboring gene tripartite motif containing 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16799 Neighboring gene TRIM52 antisense RNA 1 (head to head) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180691856-180692474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180692475-180693092 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:180694171-180694740 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:180694741-180695310

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef The binding of HIV-1 Nef with Rack1 (receptor for activated C kinase 1) is mediated by amino acids 34-143 in Nef; Rack1 acts as a Nef intracellular docking site, bringing Nef and PKCs together PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, guanine nucleotide binding protein, beta polypeptide 2-like 1 (GNB2L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Tat tat Guanine nucleotide binding protein subunit beta polypeptide 2-like 1 (GNB2L1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    matrix gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables BH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ion channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables signaling receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gastrulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rescue of stalled ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of IRE1-RACK1-PP2A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein RACK1
    Names
    cell proliferation-inducing gene 21 protein
    guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
    guanine nucleotide binding protein beta polypeptide 2-like 1
    guanine nucleotide-binding protein subunit beta-2-like 1
    guanine nucleotide-binding protein subunit beta-like protein 12.3
    human lung cancer oncogene 7 protein
    lung cancer oncogene 7
    proliferation-inducing gene 21
    protein homologous to chicken B complex protein, guanine nucleotide binding
    receptor of activated protein C kinase 1
    receptor of activated protein kinase C 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006098.5NP_006089.1  small ribosomal subunit protein RACK1

      See identical proteins and their annotated locations for NP_006089.1

      Status: VALIDATED

      Source sequence(s)
      AC008443, AK222488, BC029996, M24194
      Consensus CDS
      CCDS34324.1
      UniProtKB/Swiss-Prot
      B3KTJ0, D3DWS0, P25388, P63244, P99049, Q53HU2, Q5J8M6, Q5VLR4, Q6FH47
      UniProtKB/TrEMBL
      D6RAC2, E9KL35
      Related
      ENSP00000426909.1, ENST00000512805.6
      Conserved Domains (2) summary
      cd00200
      Location:7311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1861
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      181236897..181243906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181796848..181803858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)