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    Fbxw11 F-box and WD-40 domain protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 103583, updated on 3-Feb-2019

    Summary

    Official Symbol
    Fbxw11provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 11provided by MGI
    Primary source
    MGI:MGI:2144023
    See related
    Ensembl:ENSMUSG00000020271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HOS; BTRC2; BTRCP2; Fbxw1b; AA536858; 2310065A07Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 24.5), whole brain E14.5 (RPKM 24.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fbxw11 in Genome Data Viewer
    Location:
    11; 11 A4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (32642003..32746816)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (32542875..32646816)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 2 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene serine/threonine kinase 10 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35723 Neighboring gene small integral membrane protein 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 11
    Names
    F-box and WD repeats protein beta-TrCP2
    F-box and WD-40 domain protein 1B
    F-box/WD repeat-containing protein 1B
    homologous to Slimb protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271347.1NP_001258276.1  F-box/WD repeat-containing protein 11 isoform b

      See identical proteins and their annotated locations for NP_001258276.1

      Status: VALIDATED

      Source sequence(s)
      AK149139, AL669951, CA326854
      Consensus CDS
      CCDS70157.1
      UniProtKB/Swiss-Prot
      Q5SRY7
      Related
      ENSMUSP00000090893.6, ENSMUST00000093205.12
      Conserved Domains (5) summary
      COG2319
      Location:227527
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:240518
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:78116
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:120167
      F-box-like; F-box-like
      sd00039
      Location:243278
      7WD40; WD40 repeat [structural motif]
    2. NM_001271348.1NP_001258277.1  F-box/WD repeat-containing protein 11 isoform c

      See identical proteins and their annotated locations for NP_001258277.1

      Status: VALIDATED

      Source sequence(s)
      AK041532, AL669951, CA326854
      Consensus CDS
      CCDS70158.1
      UniProtKB/Swiss-Prot
      Q5SRY7
      Related
      ENSMUSP00000104991.1, ENSMUST00000109366.7
      Conserved Domains (5) summary
      COG2319
      Location:214514
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:227505
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:65103
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:107154
      F-box-like; F-box-like
      sd00039
      Location:230265
      7WD40; WD40 repeat [structural motif]
    3. NM_001271349.1NP_001258278.1  F-box/WD repeat-containing protein 11 isoform d

      See identical proteins and their annotated locations for NP_001258278.1

      Status: VALIDATED

      Source sequence(s)
      AK168667, AL669951, CA326854
      UniProtKB/Swiss-Prot
      Q5SRY7
      Conserved Domains (4) summary
      cd00200
      Location:206484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:209244
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4482
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:86133
      F-box-like; F-box-like
    4. NM_001363353.1NP_001350282.1  F-box/WD repeat-containing protein 11 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL669844, AL669951
      Conserved Domains (4) summary
      cd00200
      Location:208486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:211246
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4684
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:88135
      F-box-like; F-box-like
    5. NM_001363354.1NP_001350283.1  F-box/WD repeat-containing protein 11 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL669844, AL669951
      Conserved Domains (4) summary
      cd00200
      Location:208486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:211246
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4684
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:88135
      F-box-like; F-box-like
    6. NM_001363355.1NP_001350284.1  F-box/WD repeat-containing protein 11 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL669844, AL669951
      Conserved Domains (4) summary
      cd00200
      Location:142420
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:145180
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:2269
      F-box-like; F-box-like
      cl26390
      Location:118
      Beta-TrCP_D; D domain of beta-TrCP
    7. NM_134015.3NP_598776.1  F-box/WD repeat-containing protein 11 isoform a

      See identical proteins and their annotated locations for NP_598776.1

      Status: VALIDATED

      Source sequence(s)
      AK041532, AL669951, CB526764
      Consensus CDS
      CCDS36125.1
      UniProtKB/Swiss-Prot
      Q5SRY7
      Related
      ENSMUSP00000075721.7, ENSMUST00000076383.7
      Conserved Domains (5) summary
      COG2319
      Location:248548
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:261539
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:99137
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:141188
      F-box-like; F-box-like
      sd00039
      Location:264299
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      32642003..32746816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514433.2XP_006514496.1  F-box/WD repeat-containing protein 11 isoform X1

      Conserved Domains (5) summary
      COG2319
      Location:216516
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:229507
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:67105
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:109156
      F-box-like; F-box-like
      sd00039
      Location:232267
      7WD40; WD40 repeat [structural motif]
    2. XM_006514435.2XP_006514498.1  F-box/WD repeat-containing protein 11 isoform X3

      Conserved Domains (4) summary
      cd00200
      Location:208486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:211246
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4684
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:88135
      F-box-like; F-box-like
    3. XM_006514434.3XP_006514497.1  F-box/WD repeat-containing protein 11 isoform X2

      Conserved Domains (4) summary
      cd00200
      Location:208486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:211246
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:4684
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:88135
      F-box-like; F-box-like
    4. XM_006514436.3XP_006514499.1  F-box/WD repeat-containing protein 11 isoform X4

      Conserved Domains (4) summary
      cd00200
      Location:142420
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:145180
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:2269
      F-box-like; F-box-like
      cl26390
      Location:118
      Beta-TrCP_D; D domain of beta-TrCP
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