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    Xpo1 exportin 1 [ Mus musculus (house mouse) ]

    Gene ID: 103573, updated on 23-Jun-2021

    Summary

    Official Symbol
    Xpo1provided by MGI
    Official Full Name
    exportin 1provided by MGI
    Primary source
    MGI:MGI:2144013
    See related
    Ensembl:ENSMUSG00000020290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crm; Crm1; Exp1; AA420417
    Expression
    Broad expression in CNS E11.5 (RPKM 31.7), limb E14.5 (RPKM 25.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Xpo1 in Genome Data Viewer
    Location:
    11; 11 A3.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23205909..23247597)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23255909..23297597)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (23156041..23197597)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700061J23 gene Neighboring gene predicted gene, 24398 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene predicted gene, 22753 Neighboring gene AHA1, activator of heat shock protein ATPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ribosomal large subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ribosomal small subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    exportin-1
    Names
    chromosome region maintenance 1 protein homolog
    exportin 1, CRM1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035226.1NP_001030303.1  exportin-1

      See identical proteins and their annotated locations for NP_001030303.1

      Status: VALIDATED

      Source sequence(s)
      AK037196, BC062912
      Consensus CDS
      CCDS24475.1
      UniProtKB/Swiss-Prot
      Q6P5F9
      UniProtKB/TrEMBL
      Q8BYY5
      Related
      ENSMUSP00000105178.2, ENSMUST00000109551.8
      Conserved Domains (1) summary
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    2. NM_134014.3NP_598775.2  exportin-1

      See identical proteins and their annotated locations for NP_598775.2

      Status: VALIDATED

      Source sequence(s)
      AK037196, BC062912, CD347786
      Consensus CDS
      CCDS24475.1
      UniProtKB/Swiss-Prot
      Q6P5F9
      UniProtKB/TrEMBL
      Q8BYY5
      Related
      ENSMUSP00000020538.7, ENSMUST00000020538.13
      Conserved Domains (1) summary
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23205909..23247597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514430.3XP_006514493.1  exportin-1 isoform X1

      See identical proteins and their annotated locations for XP_006514493.1

      UniProtKB/Swiss-Prot
      Q6P5F9
      Related
      ENSMUSP00000099933.2, ENSMUST00000102869.8
      Conserved Domains (1) summary
      COG5101
      Location:151044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    2. XM_017314209.3XP_017169698.1  exportin-1 isoform X3

      Conserved Domains (1) summary
      COG5101
      Location:1913
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    3. XM_017314208.3XP_017169697.1  exportin-1 isoform X2

      Conserved Domains (1) summary
      COG5101
      Location:10978
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
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