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    Psme4 proteasome (prosome, macropain) activator subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 103554, updated on 23-Jun-2021

    Summary

    Official Symbol
    Psme4provided by MGI
    Official Full Name
    proteasome (prosome, macropain) activator subunit 4provided by MGI
    Primary source
    MGI:MGI:2143994
    See related
    Ensembl:ENSMUSG00000040850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TEMO; AA409398; AU041366; mKIAA0077
    Expression
    Ubiquitous expression in testis adult (RPKM 36.4), heart adult (RPKM 19.6) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Psme4 in Genome Data Viewer
    Location:
    11; 11 A4
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30721753..30831150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30771775..30881150)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (30671775..30780361)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene acylphosphatase 2, muscle type Neighboring gene coiled-coil domain containing 47 pseudogene Neighboring gene ribosomal protein L7-like 1 pseudogene Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0077

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spermatoproteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of spermatoproteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome activator complex subunit 4
    Names
    proteasome activator PA200

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134013.3NP_598774.2  proteasome activator complex subunit 4

      See identical proteins and their annotated locations for NP_598774.2

      Status: VALIDATED

      Source sequence(s)
      AF296169, AK131932, AK169447, AL662891, BE944080, CV557020, CV557303, CX566261
      Consensus CDS
      CCDS36124.1
      UniProtKB/Swiss-Prot
      Q5SSW2
      Related
      ENSMUSP00000045460.8, ENSMUST00000041231.14
      Conserved Domains (3) summary
      pfam11919
      Location:17571842
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:330828
      BLM10_mid; Proteasome-substrate-size regulator, mid region
      sd00044
      Location:15711591
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      30721753..30831150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243649.4XP_011241951.1  proteasome activator complex subunit 4 isoform X1

      Conserved Domains (1) summary
      pfam16507
      Location:330828
      BLM10_mid; Proteasome-substrate-size regulator, mid region
    2. XM_036156189.1XP_036012082.1  proteasome activator complex subunit 4 isoform X2

      Conserved Domains (3) summary
      sd00044
      Location:13801400
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:15661651
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:139637
      BLM10_mid; Proteasome-substrate-size regulator, mid region
    3. XM_030245449.1XP_030101309.1  proteasome activator complex subunit 4 isoform X3

      Conserved Domains (2) summary
      sd00044
      Location:729749
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:9151000
      DUF3437; Domain of unknown function (DUF3437)
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