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    Cep57l1 centrosomal protein 57-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 103268, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cep57l1provided by MGI
    Official Full Name
    centrosomal protein 57-like 1provided by MGI
    Primary source
    MGI:MGI:1915511
    See related
    Ensembl:ENSMUSG00000019813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cep57R; AI607327; 2410017P07Rik; 4930484D11Rik
    Expression
    Broad expression in testis adult (RPKM 5.8), CNS E11.5 (RPKM 4.2) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cep57l1 in Genome Data Viewer
    Location:
    10; 10 B2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41594836..41686413, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41718840..41809868, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (41438652..41529436, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730435O14 gene Neighboring gene coiled-coil domain containing 162 Neighboring gene microRNA 3473b Neighboring gene cDNA sequence BC048559 Neighboring gene sestrin 1 Neighboring gene armadillo repeat containing 2 Neighboring gene annexin A2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrosomal protein CEP57L1
    Names
    centrosomal protein 57kDa-like protein 1
    centrosomal protein of 57 kDa-related protein
    cep57-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243074.1NP_001230003.1  centrosomal protein CEP57L1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530, AK012710
      UniProtKB/Swiss-Prot
      Q8VDS7
      Conserved Domains (2) summary
      pfam06657
      Location:281352
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76241
      Cep57_CLD; Centrosome localization domain of Cep57
    2. NM_001243075.1NP_001230004.1  centrosomal protein CEP57L1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530, AK012710
      UniProtKB/Swiss-Prot
      Q8VDS7
      Related
      ENSMUSP00000141031.2, ENSMUST00000190022.7
      Conserved Domains (2) summary
      pfam06657
      Location:234305
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76177
      Cep57_CLD; Centrosome localization domain of Cep57
    3. NM_026643.6NP_080919.3  centrosomal protein CEP57L1 isoform 2

      See identical proteins and their annotated locations for NP_080919.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530
      Consensus CDS
      CCDS23808.1
      UniProtKB/TrEMBL
      B2RR53
      Related
      ENSMUSP00000140389.2, ENSMUST00000187143.7
      Conserved Domains (2) summary
      pfam06657
      Location:254327
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50215
      Cep57_CLD; Centrosome localization domain of Cep57
    4. NM_029132.2NP_083408.1  centrosomal protein CEP57L1 isoform 1

      See identical proteins and their annotated locations for NP_083408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115297, AC161426, AK010530
      Consensus CDS
      CCDS48549.1
      UniProtKB/TrEMBL
      G5E828
      Related
      ENSMUSP00000139509.2, ENSMUST00000186239.7
      Conserved Domains (2) summary
      pfam06657
      Location:283356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      41594836..41686413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155463.1XP_036011356.1  centrosomal protein CEP57L1 isoform X6

      Conserved Domains (2) summary
      pfam06657
      Location:299372
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:66243
      Cep57_CLD; Centrosome localization domain of Cep57
    2. XM_036155471.1XP_036011364.1  centrosomal protein CEP57L1 isoform X11

      Conserved Domains (2) summary
      pfam06657
      Location:270343
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:66231
      Cep57_CLD; Centrosome localization domain of Cep57
    3. XM_036155469.1XP_036011362.1  centrosomal protein CEP57L1 isoform X10

      Conserved Domains (2) summary
      pfam06657
      Location:283356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57
    4. XM_036155479.1XP_036011372.1  centrosomal protein CEP57L1 isoform X16

      Conserved Domains (1) summary
      pfam14073
      Location:76254
      Cep57_CLD; Centrosome localization domain of Cep57
    5. XM_036155460.1XP_036011353.1  centrosomal protein CEP57L1 isoform X3

      Conserved Domains (2) summary
      pfam06657
      Location:309382
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76253
      Cep57_CLD; Centrosome localization domain of Cep57
    6. XM_036155480.1XP_036011373.1  centrosomal protein CEP57L1 isoform X17

      Conserved Domains (2) summary
      pfam06657
      Location:158231
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:26102
      Cep57_CLD; Centrosome localization domain of Cep57
    7. XM_036155473.1XP_036011366.1  centrosomal protein CEP57L1 isoform X13

      Conserved Domains (2) summary
      pfam06657
      Location:264337
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76225
      Cep57_CLD; Centrosome localization domain of Cep57
    8. XM_036155464.1XP_036011357.1  centrosomal protein CEP57L1 isoform X7

      Conserved Domains (2) summary
      pfam06657
      Location:293366
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76237
      Cep57_CLD; Centrosome localization domain of Cep57
    9. XM_036155481.1XP_036011374.1  centrosomal protein CEP57L1 isoform X18

      Conserved Domains (2) summary
      pfam06657
      Location:129202
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:2690
      Cep57_CLD; Centrosome localization domain of Cep57
    10. XM_036155472.1XP_036011365.1  centrosomal protein CEP57L1 isoform X12

      Conserved Domains (2) summary
      pfam06657
      Location:267340
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50211
      Cep57_CLD; Centrosome localization domain of Cep57
    11. XM_036155474.1XP_036011367.1  centrosomal protein CEP57L1 isoform X14

      Related
      ENSMUSP00000140147.2, ENSMUST00000189770.7
      Conserved Domains (2) summary
      pfam06657
      Location:254327
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50215
      Cep57_CLD; Centrosome localization domain of Cep57
    12. XM_036155482.1XP_036011375.1  centrosomal protein CEP57L1 isoform X19

      Conserved Domains (2) summary
      pfam06657
      Location:122195
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:166
      Cep57_CLD; Centrosome localization domain of Cep57
    13. XM_036155467.1XP_036011360.1  centrosomal protein CEP57L1 isoform X10

      Conserved Domains (2) summary
      pfam06657
      Location:283356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57
    14. XM_036155462.1XP_036011355.1  centrosomal protein CEP57L1 isoform X5

      Conserved Domains (2) summary
      pfam06657
      Location:301374
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:68245
      Cep57_CLD; Centrosome localization domain of Cep57
    15. XM_036155470.1XP_036011363.1  centrosomal protein CEP57L1 isoform X10

      Conserved Domains (2) summary
      pfam06657
      Location:283356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57
    16. XM_036155468.1XP_036011361.1  centrosomal protein CEP57L1 isoform X10

      Conserved Domains (2) summary
      pfam06657
      Location:283356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57
    17. XM_036155476.1XP_036011369.1  centrosomal protein CEP57L1 isoform X12

      Conserved Domains (2) summary
      pfam06657
      Location:267340
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50211
      Cep57_CLD; Centrosome localization domain of Cep57
    18. XM_036155478.1XP_036011371.1  centrosomal protein CEP57L1 isoform X15

      Conserved Domains (1) summary
      pfam14073
      Location:102280
      Cep57_CLD; Centrosome localization domain of Cep57
    19. XM_036155459.1XP_036011352.1  centrosomal protein CEP57L1 isoform X2

      Conserved Domains (2) summary
      pfam06657
      Location:319392
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102263
      Cep57_CLD; Centrosome localization domain of Cep57
    20. XM_036155466.1XP_036011359.1  centrosomal protein CEP57L1 isoform X9

      Conserved Domains (2) summary
      pfam06657
      Location:290363
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102251
      Cep57_CLD; Centrosome localization domain of Cep57
    21. XM_036155458.1XP_036011351.1  centrosomal protein CEP57L1 isoform X1

      Conserved Domains (2) summary
      pfam06657
      Location:335408
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102279
      Cep57_CLD; Centrosome localization domain of Cep57
    22. XM_036155461.1XP_036011354.1  centrosomal protein CEP57L1 isoform X4

      Conserved Domains (2) summary
      pfam06657
      Location:306379
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:102267
      Cep57_CLD; Centrosome localization domain of Cep57
    23. XM_036155477.1XP_036011370.1  centrosomal protein CEP57L1 isoform X14

      Related
      ENSMUSP00000101144.4, ENSMUST00000105505.10
      Conserved Domains (2) summary
      pfam06657
      Location:254327
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50215
      Cep57_CLD; Centrosome localization domain of Cep57
    24. XM_036155475.1XP_036011368.1  centrosomal protein CEP57L1 isoform X10

      Conserved Domains (2) summary
      pfam06657
      Location:283356
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57
    25. XM_036155465.1XP_036011358.1  centrosomal protein CEP57L1 isoform X8

      Conserved Domains (2) summary
      pfam06657
      Location:292365
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:59236
      Cep57_CLD; Centrosome localization domain of Cep57
    26. XM_036155483.1XP_036011376.1  centrosomal protein CEP57L1 isoform X19

      Conserved Domains (2) summary
      pfam06657
      Location:122195
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:166
      Cep57_CLD; Centrosome localization domain of Cep57
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