Format

Send to:

Choose Destination
    • Showing Current items.

    Cep57l1 centrosomal protein 57-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 103268, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cep57l1provided by MGI
    Official Full Name
    centrosomal protein 57-like 1provided by MGI
    Primary source
    MGI:MGI:1915511
    See related
    Ensembl:ENSMUSG00000019813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cep57R; AI607327; 2410017P07Rik; 4930484D11Rik
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Broad expression in testis adult (RPKM 5.8), CNS E11.5 (RPKM 4.2) and 20 other tissues See more
    Orthologs

    Genomic context

    See Cep57l1 in Genome Data Viewer
    Location:
    10; 10 B2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (41718840..41809868, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (41438652..41529436, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730435O14 gene Neighboring gene coiled-coil domain containing 162 Neighboring gene microRNA 3473b Neighboring gene cDNA sequence BC048559 Neighboring gene predicted gene, 46222 Neighboring gene sestrin 1 Neighboring gene armadillo repeat containing 2 Neighboring gene annexin A2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrosomal protein CEP57L1
    Names
    centrosomal protein 57kDa-like protein 1
    centrosomal protein of 57 kDa-related protein
    cep57-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243074.1NP_001230003.1  centrosomal protein CEP57L1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530, AK012710
      UniProtKB/Swiss-Prot
      Q8VDS7
      Conserved Domains (2) summary
      pfam06657
      Location:281352
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76241
      Cep57_CLD; Centrosome localization domain of Cep57
    2. NM_001243075.1NP_001230004.1  centrosomal protein CEP57L1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate upstream start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530, AK012710
      UniProtKB/Swiss-Prot
      Q8VDS7
      Related
      ENSMUSP00000141031.1, ENSMUST00000190022.6
      Conserved Domains (2) summary
      pfam06657
      Location:234305
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:76177
      Cep57_CLD; Centrosome localization domain of Cep57
    3. NM_026643.5NP_080919.3  centrosomal protein CEP57L1 isoform 2

      See identical proteins and their annotated locations for NP_080919.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC115297, AC161426, AK010530
      Consensus CDS
      CCDS23808.1
      UniProtKB/TrEMBL
      B2RR53
      Related
      ENSMUSP00000101144.3, ENSMUST00000105505.9
      Conserved Domains (2) summary
      pfam06657
      Location:255326
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50215
      Cep57_CLD; Centrosome localization domain of Cep57
    4. NM_029132.2NP_083408.1  centrosomal protein CEP57L1 isoform 1

      See identical proteins and their annotated locations for NP_083408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115297, AC161426, AK010530
      Consensus CDS
      CCDS48549.1
      UniProtKB/TrEMBL
      G5E828
      Related
      ENSMUSP00000139509.1, ENSMUST00000186239.6
      Conserved Domains (2) summary
      pfam06657
      Location:284355
      Cep57_MT_bd; Centrosome microtubule-binding domain of Cep57
      pfam14073
      Location:50227
      Cep57_CLD; Centrosome localization domain of Cep57

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      41718840..41809868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center