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    Pan2 PAN2 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

    Gene ID: 103135, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pan2provided by MGI
    Official Full Name
    PAN2 poly(A) specific ribonuclease subunitprovided by MGI
    Primary source
    MGI:MGI:1918984
    See related
    Ensembl:ENSMUSG00000005682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Usp52; AI047843; AW742773; mKIAA0710; 1200014O24Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.4), limb E14.5 (RPKM 15.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pan2 in Genome Data Viewer
    Location:
    10; 10 D3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (128303331..128321358)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127740391..127758403)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 2 Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene citrate synthase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear-transcribed mRNA catabolic process, exonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PAN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PAN complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PAN2-PAN3 deadenylation complex catalytic subunit Pan2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2
    Names
    AN2 polyA specific ribonuclease subunit homolog
    PAB-dependent poly(A)-specific ribonuclease subunit 2
    PAB1P-dependent poly(A)-nuclease
    PAN deadenylation complex catalytic subunit 2
    PAN2 polyA specific ribonuclease subunit homolog
    inactive ubiquitin carboxyl-terminal hydrolase 52
    poly(A)-nuclease deadenylation complex subunit 2
    ubiquitin specific peptidase 52
    ubiquitin specific protease 52
    NP_001239255.1
    NP_001239256.1
    NP_598753.1
    XP_006513048.1
    XP_006513049.1
    XP_006513050.1
    XP_006513051.1
    XP_006513052.1
    XP_006513053.1
    XP_017169245.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252326.1NP_001239255.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2

      See identical proteins and their annotated locations for NP_001239255.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC135859, AK004773, BC079841, CF170307
      UniProtKB/Swiss-Prot
      Q8BGF7
      Related
      ENSMUSP00000151216.1, ENSMUST00000218315.1
      Conserved Domains (4) summary
      cd06143
      Location:9651138
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:501911
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516888
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001252327.1NP_001239256.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC135859, AK004773, AK157800, BG086688
      UniProtKB/Swiss-Prot
      Q8BGF7
      Related
      ENSMUSP00000151874.1, ENSMUST00000219721.1
      Conserved Domains (4) summary
      cd06143
      Location:9471120
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:483893
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:498870
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75339
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001358822.1NP_001345751.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC135859, AK004773, AK047887, CN527165, CX566326
      Conserved Domains (3) summary
      cd06143
      Location:8361009
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:362782
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl25539
      Location:21218
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_133992.3NP_598753.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1

      See identical proteins and their annotated locations for NP_598753.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC135859, AK004773, AK047887
      Consensus CDS
      CCDS24271.1
      UniProtKB/Swiss-Prot
      Q8BGF7
      Related
      ENSMUSP00000005825.6, ENSMUST00000005825.7
      Conserved Domains (4) summary
      cd06143
      Location:9741147
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:501920
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516897
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      128303331..128321358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512985.2XP_006513048.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X1

      Conserved Domains (4) summary
      cd06143
      Location:9791152
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:501925
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516902
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006512989.1XP_006513052.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X5

      Conserved Domains (4) summary
      cd02672
      Location:501925
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516902
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl10012
      Location:9791092
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    3. XM_006512988.2XP_006513051.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X4

      Conserved Domains (4) summary
      cd06143
      Location:9701143
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:501916
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516893
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_006512987.2XP_006513050.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X3

      Conserved Domains (4) summary
      cd06143
      Location:9751148
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:501921
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516898
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_006512986.2XP_006513049.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X2

      Conserved Domains (4) summary
      cd06143
      Location:9781151
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:501924
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:516901
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:75357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_006512990.2XP_006513053.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X6

      Conserved Domains (4) summary
      cd06143
      Location:8401013
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:362786
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:377763
      UCH_1; Ubiquitin carboxyl-terminal hydrolase
      cl02567
      Location:21218
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_017313756.1XP_017169245.1  PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X7

      Conserved Domains (3) summary
      cd06143
      Location:8361009
      PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
      cd02672
      Location:362782
      Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl25539
      Location:21218
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_380329.2 RNA Sequence

    2. XR_001779394.1 RNA Sequence

    3. XR_380330.2 RNA Sequence

    4. XR_380328.1 RNA Sequence

      Related
      ENSMUST00000219255.1
    5. XR_001779395.1 RNA Sequence

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